Difference between revisions of "Floxuridine"
m (Removed Category:Pyrimidines; Adding category Category:Pyrimidones (using HotCat)) |
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Latest revision as of 23:54, 10 September 2010
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File:Floxuridine.png | |
Systematic (IUPAC) name | |
---|---|
5-Fluoro-1-[4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-1H-pyrimidine-2,4-dione | |
Identifiers | |
CAS Number | 50-91-9 |
ATC code | none |
PubChem | CID 5790 |
DrugBank | APRD00692 |
Chemical data | |
Formula | C9H11FN2O5 |
Molar mass | 246.192 g/mol[[Script error: No such module "String".]] |
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Floxuridine is an oncology drug that belongs to the class known as antimetabolites. The drug is most often used in the treatment of colorectal cancer.
Pharmacology
Floxuridine, an analog of 5-fluorouracil, is a fluorinated pyrimidine.
Mechanism of action
Floxuridine works because it is broken down by the body into its active form, which is the same as a metabolite of 5-Fluorouracil.
History
Floxuridine first gained FDA approval in December 1970 under the brand name FUDR. The drug was initially marketed by Roche, which also did a lot of the initial work on 5-fluorouracil. The National Cancer Institute was an early developer of the drug. Roche sold its FUDR product line in 2001 to F H Faulding, which became Mayne Pharma.
Suppliers
In the US the drug is supplied by APP Pharmaceuticals, LLC; Hospira, Inc.; and Bedford Laboratories.
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