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...ition to being an H-1 [[histamine]] [[Receptor (biochemistry)|receptor]] [[Receptor antagonist|antagonist]], chlorpheniramine has been shown to work as a [[ser [[Category:H1 receptor antagonists]]

...n augment the [[antiemetic]] effect of [[5-HT3 antagonist|5-HT₃ receptor antagonists]] like [[ondansetron]]. In [[brain tumour]]s (primary or metas [[pt:Dexametasona]]

...an activate and influence biochemical behaviour of most cells. The steroid/receptor complexes dimerise and interact with cellular DNA in the nucleus, binding t [[pt:Prednisolona]]

....<ref>Granger, P. et al. Modulation of the gamma-aminobutyric acid type A receptor by the antiepileptic drugs carbamazepine and phenytoin. Mol. Pharmacol. 47, ...128 |doi= 10.1097/00002826-200007000-00010|url=http://meta.wkhealth.com/pt/pt-core/template-journal/lwwgateway/media/landingpage.htm?issn=0362-5664&volum

...is specifically induced by Phenobarbital via the [[CAR]]/[[RXR]] [[nuclear receptor]] [[heterodimer]]. It is excreted primarily by the [[kidney]]s. [[pt:Fenobarbital]]

...to D-cycloserine's action as a partial [[agonist]] of the neuronal [[NMDA receptor]] for [[glutamate]] and have been examined in implications with sensory-rel D-cycloserine is a [[partial agonist]] at the [[glycine receptor]], and has been shown to have cognition-enhancing properties for models of

...morphine, exert their effects by binding to and activating the μ-[[opioid receptor]]. ...n|first2=MR|last3=Diphillipo|first3=MA|last4=Forst-Paulus|first4=M|issue=1 Pt 2}}</ref> (Off-label)

...cts. It is a [[competitive antagonist]] for the [[muscarinic acetylcholine receptor]]. It is classified as an [[anticholinergic drug]]. Being potentially dead ...of the [[vagus nerve]], blocks [[acetylcholine]] [[receptor (biochemistry)|receptor]] sites, and decreases [[bronchial]] [[secretion]]s.

...shizawa K, Aoki K, Takagi M, Miyatake M, Suzuki T |title=A putative sigma1 receptor antagonist NE-100 attenuates the discriminative stimulus effects of ketamin ...e the effect to ketamine being an [[N-methyl-D-aspartate receptor|NMDA]] [[receptor antagonist]].<ref>{{Cite journal|author=Zarate CA, Singh JB, Carlson PJ, ''

...rst4= JM |first5= D |first6= G |first7= G |first8= Investigators |issue= 6 Pt 1 |last2= Tonnelier |last3= D'athis |last4= Tréluyer |last5= Gendrel |last ...INR should be monitored closely. They may also interact with the [[GABA A receptor]] and cause neurological symptoms; this effect is augmented by certain [[no

...benzodiazepines acting on the benzodiazepine site on the GABA_A receptor increase the opening frequency of the chloride ion channel. This explains w ...January | title = Intravenous anaesthetics inhibit nicotinic acetylcholine receptor-mediated currents and Ca2+ transients in rat intracardiac ganglion neurons.

...c=558205 }}</ref><ref>{{vcite journal |author=Libby G, Donnelly LA, Donnan PT, Alessi DR, Morris AD, Evans JM |year=2009 |title=New users of metformin ar ...gh AMP-activated protein kinase-dependent regulation of the orphan nuclear receptor SHP |journal=Diabetes |volume=57 |issue=2 |pages=306–14 |year=2008 |pmid=

...HT in rat prefrontal cortex and hypothalamus: an in vivo microdialysis and receptor binding study |journal=Neuropsychopharmacology |volume=27 |issue=6 |pages=9 ..., Casis O, Casis L |title=Effects of fluoxetine administration on mu-opoid receptor immunostaining in the rat forebrain |journal=Brain Res. |volume=817 |issue=

...the experiments in rats, via the action on [[arachidonic acid]] and [[NMDA receptor]]s cascade.<ref name="Gutton">{{Cite journal|author=Guitton MJ, Caston J, R [[pt:Ácido acetilsalicílico]]

...enegger M |title=Use-dependent inhibition of the skeletal muscle ryanodine receptor by the suramin analogue NF676 |journal=Br. J. Pharmacol. |volume=146 |issue [[pt:Suramina]]

...enolol''' ('''Tenormin''') is a selective [[beta-1 receptor|β₁ receptor]] [[receptor_antagonist|antagonist]], a [[drug]] belonging to the group of ...lpha-agonists (e.g. [[clonidine]]), [[ACE Inhibitor]]s or [[Angiotensin II receptor antagonist]]s such as losartan can also be given additionally. Exert cautio

...development, the &alpha;₆&beta;₂&gamma;₂ receptor increases in expression in cerebellar granule neurons, corresponding to inc [[pt:Furosemida]]

...D₃]], [[Dopamine D4 receptor|D₄]], and [[Dopamine D5 receptor|D₅]]—and their variants. Dopamine is produced in several areas Via the [[dopamine receptor]]s, D_1-5, dopamine reduces the influence of the indirect pathway

'''Timolol maleate''' is a non-selective [[beta blocker|beta-adrenergic receptor blocker]]. In its oral form ('''Blocadren'''), it is used to treat [[hypert [[pt:Timolol]]

...). Spironolactone has anti-androgen activity by binding to the [[androgen receptor]] and preventing it from interacting with [[dihydrotestosterone]].<ref>{{ci ...| pmid=16840442 | pmc=1539051 }}</ref> Because it also affects [[androgen receptor]]s and other steroid receptors, it can cause [[gynecomastia]], menstrual ir

...or '''Zantac''') is a [[histamine]] [[H2-receptor antagonist|H₂-receptor antagonist]] that inhibits [[gastric acid|stomach acid]] production. It is {{Main|H2-receptor antagonist}}

...short-acting [[beta2-adrenergic receptor agonist|β₂-adrenergic receptor agonist]] used for the relief of [[bronchospasm]] in conditions such as [[a Salbutamol was the first selective Β2-receptor agonist to be marketed — in 1968. It was first sold by Allen & Hanburys u

...tion]] and [[mucus]] [[secretion]]. It is a non-selective [[muscarinic]] [[Receptor antagonist|antagonist]], and does not diffuse into the blood, which prevent [[pt:Ipratrópio]]

...or|5-HT₃ receptor]] antagonist/[[5-HT receptor|5-HT₄ receptor]] agonist. ...activity, D₂ receptor antagonist activity and 5-HT₄ receptor agonist activity.<ref name="Martindale34">Sweetman S, editor. Martindale: T

...s Type I and Type II receptor agonist), or [[RU28362]] (a specific Type II receptor agonist), to adrenalectomized animals induced changes in [[leukocyte distri .... Aldosterone and cortisol have similar affinity for the mineralocorticoid receptor however, glucocorticoids circulate at roughly 100 times the level of minera

{{See also|Adrenergic receptor}} ...ues. Its actions vary by tissue type and tissue expression of [[adrenergic receptor]]s. For example, epinephrine causes [[smooth muscle]] relaxation in the air

...= 1095–101|year = 2000|pmid = 11020766|url = http://meta.wkhealth.com/pt/pt-core/template-journal/lwwgateway/media/landingpage.htm?issn=0003-3022&volum ...7862891}}</ref> Indeed, in humans given 30% N₂O, benzodiazepine receptor antagonists reduced the subjective reports of feeling "high", but did not a

...that apparently only reacted to morphine: the mu3 [[Opioid receptor|opiate receptor]] in human tissue.<ref>{{cite journal |author=Zhu W, Cadet P, Baggerman G, ...morphine|journal=Journal of Physiology and Pharmacology|volume=55|issue=1 Pt 2|pages=279–288|date=March 2004|pmid=15082884|last2=Zhu|first2=W|last3=Ca

...in receptor (nociceptor) of the body, the [[TRPV1]] (older name: vanilloid receptor). Furthermore, AM404 inhibits sodium channels, as do the anesthetics lidoca <!--{{Link FA|pt}}http://pt.wikipedia.org/wiki/Wikipedia:Revalida%C3%A7%C3%A3o/Paracetamol-->

...''The Sympathomimetic Actions of l-Ephedrine and d-Pseudoephedrine: Direct Receptor Activation or Norepinephrine Release?''] Anesth Analg 2003; 97, pp.1239-124 ...ochemistry|steric]] orientation of the [[hydroxyl]] group is important for receptor binding and functional activity.<ref name='Ma'/>

...inding to the benzodiazepine site on the [[GABAA receptor|GABA_A receptor]] leading to [[central nervous system]] depression.<ref name="Riss-2008"/> ...irst2 = R. | last3 = Hösl | first3 = K. | title = Subtype-selective GABAA receptor mimetics--novel antihyperalgesic agents? | url = http://www.springerlink.co

...d]] (GABA) [[receptor antagonist]]. Cicutoxin acts on the GABA_A receptor causing a block of the [[chloride channel]] which results in [[neuronal dep [[pt:Cicuta]]

...nn M"/> 3) Surface enterocytes also express high levels of [[Interleukin-1 receptor]] (IL-1R) -containing inhibitory molecule. IL-1R are also referred to as si ...mponent that monitors and responds to changes in the environment. When the receptor senses a stimulus, it sends information to a '''control center''', the comp

...oscyamine]], and [[scopolamine]] antagonize the [[muscarinic acetylcholine receptor|muscarinic acetylcholine]] receptors in the eye. By blocking these receptor [[pt:Midríase]]

# nonselective [[adenosine receptor]] antagonist <ref name="AR-Daly">{{cite journal | author=Daly JW, Jacobson [[pt:Pentoxifilina]]

'''Tasosartan''' is an [[angiotensin II receptor antagonist]]. ...}}</ref><ref>{{cite journal |author=Dina R, Jafari M |title=Angiotensin II-receptor antagonists: an overview |journal=Am J Health Syst Pharm |volume=57 |issue=

...ncrease Thyroid Hormone Levels via Down-Regulation of the Aryl Hydrocarbon Receptor (AhR) Target Gene UDP-Glucuronosyltransferase|journal=Environmental Health [[pt:Poliestireno]]

...ib''' (trade name '''Votrient''') is a potent and selective multi-targeted receptor [[tyrosine kinase inhibitor]] of [[VEGFR]]-1, VEGFR-2, VEGFR-3, [[PDGFR]]-a [[pt:Pazopanib]]

...imic the molecular shape of [[adrenaline]]. It binds to [[alpha-adrenergic receptor]]s in the nasal mucosa.<ref>{{cite pmid|20030735}}</ref> Due to its [[sympa [[pt:Xilometazolina]]

...ts action on the [[D2 receptor|D2 dopamine]] and [[5HT1A|5-HT_1A receptor]]s that can cause some side effects. <ref name="Tfelt">{{cite journal|autho [[pt:Ergotamina]]

...hydrochloride. It is a [[sympathomimetic]] agent with marked [[Adrenergic receptor|alpha adrenergic]] activity. It is a [[vasoconstrictor]] with a rapid acti [[pt:Nafazolina]]

...line in the management of epistaxis. Ann Otol Rhinol Laryngol, 1995. 104(9 Pt 1): p. 704-6.</ref> and eye redness due to minor irritation (marketed as [[ ...pression due to stimulation of central alpha-2 receptors and [[imidazoline receptor]]s, much like [[clonidine]].

...ction there. The cytokine factors then bind with [[endothelium|endothelial receptor]]s on vessel walls, or interact with local [[microglial cell]]s. When these ...ein]] (LBP) binds to LPS. The LBP–LPS complex then binds to the [[CD14]] receptor of a nearby [[macrophage]]. This binding results in the synthesis and relea

...519 |doi=10.1097/00043426-200306000-00002 |url=http://meta.wkhealth.com/pt/pt-core/template-journal/lwwgateway/media/landingpage.htm?issn=1077-4114&volum ...[[Complement Receptor 3|Macrophage-1 antigen]] ([[CD18]]) [[cell receptor|receptor]] on immune cells.<ref name=pmid15084502>{{cite pmid|15084502}} (review)</r

...the NMDA receptor, lead exposure decreased the amount of the gene for the receptor in part of the brain.<ref>{{cite web |url=http://www.jhsph.edu/publichealth ...434739}}</ref><ref name="pmid8035397">{{cite journal |author=Lin JL, Huang PT |title=Body lead stores and urate excretion in men with chronic renal disea

...driving force for the binding of drugs to their [[receptor (biochemistry)|receptor]] targets.<ref name="Eisenberg">{{cite journal |author=Eisenberg D, McLachl [[pt:Coeficiente de partição]]

...g to Le Châtelier's principle thereby explaining the diverse phenomena of receptor activation and desensitization.<ref name="Bio-balance">{{cite web|url=http: [[pt:Princípio de Le Châtelier]]

...ule, including any [[protein]], is phosphorylation. Many [[enzyme]]s and [[Receptor (proteomics)|receptors]] are switched "on" or "off" by phosphorylation. Pho ...ly into the cytoplasm. It can be recognised by the [[inositol triphosphate receptor]] (IP3R). IP3 contributes to the activation of [[protein kinase C]] (PKC).<

...[angiotensin II receptor antagonist]]s, which directly block [[Angiotensin receptor|angiotensin II AT₁ receptors]]. ...ol|DAG]] → activation of [[Inositol triphosphate receptor|IP₃ receptor]] in [[sarcoplasmic reticulum|SR]] → ↑intracellular Ca²⁺

!Receptor <BR> (↑ = opens. ↓ = closes) <ref name=boron/> <br> <font size=1> On [[ ...[[acetylcholine]] || ↑[[Muscarinic acetylcholine receptor M2|muscarinic receptor M₂]]

!Receptor <br/> (↑ = opens. ↓ = closes) <ref name=boron/> <br> <font size=1> On [ |rowspan=2| [[nitric oxide]] || ↑[[NO receptor]] on smooth muscle || ↑[[cyclic GMP|cGMP]] --> ↑[[protein kinase g|PKG]

...enin-Angiotensin System: Emphasis on Blockade of the Angiotensin II Type-1 Receptor ...(ARBs) can be used to prevent angiotensin II from acting on [[angiotensin receptor]]s.

...tp://www.nature.com/bjp/journal/v143/n4/full/0705974a.html "Selective GABA-receptor actions of amobarbital on thalamic neurons."] ''British Journal of Pharmaco ...t (military)|frontline]].<ref>[http://www.pbs.org/wgbh/amex/bulge/filmmore/pt.html Use of sodium amytal during WWII]</ref>

...month= November | year= 1975 | pages= 530&ndash;4 | volume= 18 | issue= (5 Pt 1) | pmid=1102231 | accessdate= 2008-02-22}}</ref><ref name="Phillips">{{ci ...ref> and there may be other modes of action such as through [[histamine H3 receptor]]s<ref name="Girard">{{cite journal | author= Girard P, Pansart Y, Coppé M

...ervous]] and [[immune system]]s of animals and that activate [[cannabinoid receptor]]s , and 3. '''synthetic cannabinoids''', a structurally diverse class of m {{Main|Cannabinoid receptor}}

...brain: isolation, structure elucidation, and interactions with the opiate receptor |journal=Proc Natl Acad Sci USA |volume=73 |issue=7 |pages=2515–9 |year=1 ...for the κ₁ opioid receptors. μ opioid receptors are the main receptor through which [[morphine]] acts. Classically, μ opioid receptors are presy

...elieve minor throat irritation. Menthol also acts as a weak [[kappa Opioid receptor]] [[agonist]]. [[pt:Mentol]]

...ub>1</sub>]] and [[CB2 receptor|CB₂]] [[receptor_(biochemistry)|receptor]]s, with lower [[affinity_(pharmacology)|affinity]] in comparison to [[THC] [[pt:Canabinol]]

| url = http://meta.wkhealth.com/pt/pt-core/template-journal/lwwgateway/media/landingpage.htm?issn=0271-0749&volum ...affinity for [[Cannabinoid_receptor#CB1|CB₁]] and [[Cannabinoid receptor#CB2|CB₂]] receptors but acts as an indirect antagonist of cannab

...|CB₁]] receptor, which is the most abundant [[G protein-coupled receptor]] in the [[brain]]. ...inoid receptor]] antagonist [[rimonabant]] (SR141716A) as well as [[opioid receptor]] antagonists (opioid blockers) [[naloxone]] and [[naloxonazine]].<ref name

...de Lamarck, J.B. 1785. ''Encyclopédie Méthodique de Botanique'', vol. 1, pt. 2. Paris, France, pp. 694-695</ref> Lamarck based his description of the n ...nabidiol modulates and directly activates alpha-1 and alpha-1-Beta glycine receptor function|journal = [[Pharmacology]]|volume = 83|issue = 4|pages = 217–222

...f the amyloid precursor protein | journal = J. Cell. Sci. | volume = 113 ( Pt 11) | issue = | pages = 1857–70 | year = 2000 | month = June | pmid = 108 ...comparisons to the signaling role of the surface [[transmembrane receptor|receptor]] protein [[Notch signaling|Notch]].<ref name="Selkoe">{{cite journal | aut

|| [[Dopamine receptor]]s at pathway terminations. ...gmental nuclei]] (''pontomesencephalotegmental complex'') || (mainly) [[M1 receptor]]s in:

...=|accessdate=}}</ref>&nbsp; Signal transduction starts with a signal to a receptor, and ends with a change in cell function. ...de the cell.&nbsp; The chemical signal binds to the outer portion of the receptor, changing its shape and conveying another signal inside the cell.&nbsp; So

*Some [[transient receptor potential channel]]s: This group of channels, normally referred to simply a ...nion-permeable γ-aminobutyric acid-gated [[GABA receptor|GABA_A receptor]].

Loperamide is an [[opioid]]-receptor [[agonist]] and acts on the [[Mu Opioid receptor|μ-opioid receptors]] in the [[myenteric plexus]] of the large intestine; b [[pt:Loperamida]]

...antagonist|antagonist]] activity at the [[kappa opioid receptor|κ-opioid receptor]]. Buprenorphine [[hydrochloride]] was first marketed in the 1980s by Recki Suboxone contains buprenorphine as well as the [[opioid]] [[receptor antagonist|antagonist]] [[naloxone]] to deter the abuse of tablets by [[int

...8}}</ref> In addition, it is a synthetic strong agonist at the [[mu opioid receptor|μ-opioid]] receptors. Historically it has been used to treat [[breakthroug [[pt:Fentanil]]

...lly unlike [[morphine]] or [[heroin]], methadone also acts on the [[opioid receptor]]s and thus produces many of the same effects. Methadone is also used in ma ...receptor, but also has some affinity for the [[NMDA]] ionotropic glutamate receptor. It is metabolized by the enzymes [[CYP3A4]], [[CYP2B6]] and [[CYP2D6]], wi

...2receptorsimplications for models of schizophrenia](2002)</ref> Other NMDA receptor antagonists include [[ketamine]], [[tiletamine]], and [[dextromethorphan]]. In a similar manner, PCP and analogues also inhibit [[nicotinic acetylcholine receptor]] channels (nAChR). Some analogues have greater potency at nAChR than at NM

...potent [[Kappa Opioid receptor|κ-opioid]] and [[D2 receptor|D₂ receptor]] [[agonist]].<ref name="Zhang2005pabs" /><ref name="Seeman2009">[[#refSeem ...ain a [[Base (chemistry)|basic]] [[nitrogen]]), unlike most known [[opioid receptor]] [[ligand]]s.<ref name="Harding2006p107">[[#refHarding2006|Harding, Schmid

As a narcotic, hydrocodone relieves [[pain]] by binding to [[opioid receptor]]s in the [[brain]] and [[spinal cord]]. It can be taken with or without f [[pt:Diidrocodeína]]

...ssociative]] [[hallucinogen]]. Its [[mechanism of action]] is as an [[NMDA receptor antagonist]], producing effects similar to those of the controlled substan ...7 | doi = 10.1097/ANA.0b013e31817f523f | url = http://meta.wkhealth.com/pt/pt-core/template-journal/lwwgateway/media/landingpage.htm?issn=0898-4921&volum

...It has also been shown that Alfaxalone binds to a different region of this receptor than the benzodiazipines (2). Alfaxalone is metabolised rapidly in the live ...RL, et al. A single amino acid of the human gamma-aminobutyric acid type A receptor gamma 2 subunit determines benzodiazepine efficacy. J Biol Chem 1994;269:32

...n]] [[protein dimer|dimer]] complex. The [[gene]] [[encoding]] an ethylene receptor has been cloned in ''[[Arabidopsis thaliana]]'' and then in [[tomato]]. Eth Ethylene hormone receptor action in Arabidopsis. Chang C, Stadler R. Bioessays. 2001 Jul;23(7):619-27

Etomidate is an agonist at [[GABAA receptor|GABA_A]] [[Receptor (biochemistry)|receptors]]<ref>Vanlersberghe C, Camu F. Etomidate and other [[pt:Etomidato]]

...Receptor antagonist|antagonist]] of N-methyl-d-aspartate receptors ([[NMDA receptor]]s). These receptors exacerbate the damage from [[oxygen deprivation]] and [[Category:NMDA receptor antagonists]]

...l analogues: mapping binding sites for an anesthetic phenol on the GABA(A) receptor. ''Journal of Medicinal Chemistry''. 2002 Jul 18;45(15):3210–21. PMID 121 [[pt:Propofol]]

...0s by Dr. [[Henri Laborit]] to use in studying the neurotransmitter [[GABA receptor|GABA]].<ref>{{cite journal | author = H. Laborit, J.M. Jouany, J. Gerald, F ...}</ref> and it is a weak agonist at the [[GABA receptor|GABA_B]] receptor, which is [[inhibitory]].<ref name="mechanism" /> GHB is a naturally-occurr

[[ca:Receptor superheterodí]] [[es:Receptor superheterodino]]