Uramustine
From Self-sufficiency
 | This article does not cite any references or sources. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed. (December 2009) |
| 200px | |
| Systematic (IUPAC) name | |
|---|---|
|
5-[bis(2-chloroethyl)amino]-1H-pyrimidine-2,4-dione | |
| Pharmacokinetic data | |
| Protein binding | 5% |
| Excretion | Renal |
| Identifiers | |
| CAS Number | 66-75-1 |
| ATC code | none |
| PubChem | CID 6194 |
| DrugBank | APRD00130 |
| Chemical data | |
| Formula | C8H11Cl2N3O2 |
| Molar mass | 252.097 g/mol[[Script error: No such module "String".]] |
| (verify) | |
Uramustine (INN) or uracil mustard is a chemotherapy drug which belongs to the class of alkylating agents. It is used in lymphatic malignancies such as non-Hodgkin's lymphoma. It works by damaging DNA, primarily in cancer cells that preferentially take up the uracil due to their need to make nucleic acids during their rapid cycles of cell division. The DNA damage leads to apoptosis of the affected cells. Bone marrow suppression and nausea are the main side effects.
Chemically it is a derivative of nitrogen mustard and uracil.
| 40px | This antineoplastic or immunomodulatory drug article is a stub. You can help ssf by expanding it. |
Categories:
- Pages with script errors
- Articles lacking sources from December 2009
- Articles with invalid date parameter in template
- All articles lacking sources
- Pages with broken file links
- Infobox drug tracked parameters
- Articles without EBI source
- Chemical pages without ChemSpiderID
- Articles without KEGG source
- Articles without InChI source
- Articles without UNII source
- Drugs not assigned an ATC code
- Drugs with no legal status
- Drugboxes which contain changes to watched fields
- 2Fix
- Chemotherapeutic agents
- IARC Group 2B carcinogens
- Nitrogen mustards
- Pyrimidinediones
- Organochlorides
- Antineoplastic and immunomodulating drug stubs
