Avanafil

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Avanafil
File:Avanafil.svg
Systematic (IUPAC) name
4-[(3-Chloro-4-methoxybenzyl)amino]-2-

[2-(hydroxymethyl)-1-pyrrolidinyl]-N-

(2-pyrimidinylmethyl)-5-pyrimidinecarboxamide
Clinical data
Routes of
administration		 Oral
Identifiers
CAS Number 330784-47-9
ATC code none
PubChem CID 9869929
ChemSpider 8045620
Chemical data
Formula C23H26ClN7O3
Molar mass 483.951 g/mol[[Script error: No such module "String".]]
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Avanafil (dubbed as "Son of Viagra"[1]) is a PDE5 inhibitor being developed for erectile dysfunction. Avanafil currently has no trademarked term associated with it but it is being developed by Vivus Inc. It acts by inhibiting a specific phosphodiesterase type 5 enzyme which is found in various body tissues, but primarily in the corpus cavernosum penis, as well as the retina. Other similar drugs are sildenafil, tadalafil and vardenafil.

Synthesis

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Yamada, K.; Matsuki, K.; Omori, K.; Kikkawa, K.; 2004, U.S. Patent 6,797,709.

See also

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References

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Further reading

External links

Urologicals, including antispasmodics (G04B)
Acidifiers
Urinary antispasmodics
(primarily antimuscarinics)
For erectile dysfunction
Avanafil · Sildenafil · Tadalafil · Udenafil · Vardenafil
Others
Other urologicals
PDE1
PDE2
PDE3
PDE4
PDE5
PDE6
PDE7
PDE9
PDE10
Nonselective


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pt:Avanafil
  1. ↑ "SCIENTISTS have made a "son of Viagra" pill that works extra-fast". The Sun. October 28, 2008. Retrieved 2008-10-30. 
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