Thiomethisosildenafil

Thiomethisosildenafil

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Systematic (IUPAC) name
5-{5-[(3R,5S)-3,5-dimethylpiperazin-1-ylsulfonyl]-2-ethoxyphenyl}-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidine-7(6H)-thione
Identifiers
ATC code	none
PubChem	CID 23139635
Chemical data
Formula	C23H34N6O3S2
Molar mass	506.683 g/mol[[]]

Thiomethisosildenafil is a drug which acts as a phosphodiesterase inhibitor. It is a synthetic structural analogue of sildenafil (Viagra) which has been detected in several different brands of supposedly "herbal" aphrodisiac products sold to boost libido and alleviate erectile dysfunction.

A range of designer analogues of legitimate inhibitors of type-5 cGMP-specific phosphodiesterase (PDE₅), such as sildenafil and vardenafil, have been detected in recent years as adulturants in over-the-counter herbal aphrodisiac products and dietary supplements, in an apparent attempt to circumvent both the legal restrictions on sale of erectile dysfunction drugs, which are prescription-only medicines in most Western countries, and the patent protection which prevents sale of these drugs by competitors except under license to their inventors. These compounds have been demonstrated to display PDE₅ inhibitory activity in vitro and presumably have similar effects when consumed, but have undergone no formal testing in either humans or animals, and as such represent a significant health risk to consumers of these products due to their unknown safety profile. Some attempts have been made to ban these drugs as unlicensed medicines, but progress has been slow so far, as even in those jurisdictions which have laws targeting designer drugs, the laws are drafted to ban analogues of illegal drugs of abuse, rather than analogues of prescription medicines. However at least one court case has resulted in a product being taken off the market.

See also

• Acetildenafil