Drotaverine
File:Drotaverine.svg | |
Systematic (IUPAC) name | |
---|---|
(Z)-1-(3,4-diethoxybenzylidene)-6,7-diethoxy-1,2,3,4-tetrahydroisoquinoline | |
Clinical data | |
Routes of administration | Oral, intravenous |
Pharmacokinetic data | |
Bioavailability | Highly variable |
Protein binding | 80 to 95% |
Metabolism | Hepatic |
Biological half-life | 7 to 12 hours |
Excretion | Fecal and renal |
Identifiers | |
CAS Number | 985-12-6 |
ATC code | A03AD02 (WHO) |
PubChem | CID 1712095 |
Chemical data | |
Formula | C24H31NO4 |
Molar mass | 397.507 g/mol[[Script error: No such module "String".]] |
Drotaverine (INN, also known as drotaverin) is an antispasmodic drug, structurally related to papaverine. Drotaverine is a selective inhibitor of phosphodiesterase 4, and has no anticholinergic effects.[citation needed] Drotaverine has been shown to possess dose-dependant analgesic effects in animal models.[1] One small study has shown drotaverine to be eliminated mainly non-renally.[2]
A few small 2003 studies found drotaverine to be nearly 80% effective in treating renal colic.[3][4] It has also been studied in accelerating labor by speeding up cervical dilation, but the results have been conflicting.[5][6][7] Drotaverine has been shown to be effective in managing pain during hysteroscopy and endometrial biopsy when administered together with mefenamic acid.[8] IBS patients presenting with predominant diarrhea are more likely to benefit from Buscopan.[9] Drotaverin has also been tested in combination with rimantadine for antiviral activity against A and B type influenza.[10] Drotaverin has an adverse effects frequency of 0.9%, side effects being relatively uncommon.[11]
Drotaverine in sold under brand name No-Spa (Chinoin Pharmaceutical and Chemical Works, Hungary, a member of the Sanofi-Aventis).[citation needed]
References
Cite error: Invalid <references>
tag;
parameter "group" is allowed only.
<references />
, or <references group="..." />
45px | This drug article relating to the gastrointestinal system is a stub. You can help ssf by expanding it. |
- ↑ Stepaniuk AG, Stepaniuk NG, Stoliarchuk AA, Stepaniuk GI, Chernobrovyĭ VN (1998). "[The characteristics of the analgesic action of nitrosorbide and no-shpa]". Eksperimental'naia I Klinicheskaia Farmakologiia (in Russian). 61 (4): 17–9. PMID 9783101.
- ↑ Bolaji OO, Onyeji CO, Ogundaini AO, Olugbade TA, Ogunbona FA (1996). "Pharmacokinetics and bioavailability of drotaverine in humans". European Journal of Drug Metabolism and Pharmacokinetics. 21 (3): 217–21. doi:10.1007/BF03189716. PMID 8980918.
- ↑ Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
- ↑ Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
- ↑ Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
- ↑ Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
- ↑ Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
- ↑ Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
- ↑ Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
- ↑ Zhilinskaya IN, Konovalova NI, Kiselev OI, Ashmarin IP (2007). "No-Spa and Remantadin are the novel complex preparations that inhibit effectively reproduction of the avian influenza viruses". Doklady Biological Sciences. 414: 249–50. doi:10.1134/S0012496607030234. PMID 17668635.
- ↑ Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
- Pages with script errors
- Pages with broken file links
- Infobox drug tracked parameters
- Articles without EBI source
- Chemical pages without ChemSpiderID
- Chemical pages without DrugBank identifier
- Articles without KEGG source
- Articles without InChI source
- Articles without UNII source
- Drugs with no legal status
- Articles containing unverified chemical infoboxes
- All articles with unsourced statements
- Articles with unsourced statements from May 2010
- Articles with invalid date parameter in template
- 2Fix
- Drugs acting on the gastrointestinal system and metabolism
- Isoquinolines
- Phenol ethers
- Antispasmodics
- PDE4 inhibitors
- Gastrointestinal system drug stubs
- CS1 maint: Multiple names: authors list
- CS1 maint: Unrecognized language