Drotaverine

From Self-sufficiency
Jump to: navigation, search
Drotaverine
File:Drotaverine.svg
Systematic (IUPAC) name
(Z)-1-(3,4-diethoxybenzylidene)-6,7-diethoxy-1,2,3,4-tetrahydroisoquinoline
Clinical data
Routes of
administration
Oral, intravenous
Pharmacokinetic data
Bioavailability Highly variable
Protein binding 80 to 95%
Metabolism Hepatic
Biological half-life 7 to 12 hours
Excretion Fecal and renal
Identifiers
CAS Number 985-12-6
ATC code A03AD02 (WHO)
PubChem CID 1712095
Chemical data
Formula C24H31NO4
Molar mass 397.507 g/mol[[Script error: No such module "String".]]
Script error: No such module "TemplatePar".Expression error: Unexpected < operator.

Drotaverine (INN, also known as drotaverin) is an antispasmodic drug, structurally related to papaverine. Drotaverine is a selective inhibitor of phosphodiesterase 4, and has no anticholinergic effects.[citation needed] Drotaverine has been shown to possess dose-dependant analgesic effects in animal models.[1] One small study has shown drotaverine to be eliminated mainly non-renally.[2]

A few small 2003 studies found drotaverine to be nearly 80% effective in treating renal colic.[3][4] It has also been studied in accelerating labor by speeding up cervical dilation, but the results have been conflicting.[5][6][7] Drotaverine has been shown to be effective in managing pain during hysteroscopy and endometrial biopsy when administered together with mefenamic acid.[8] IBS patients presenting with predominant diarrhea are more likely to benefit from Buscopan.[9] Drotaverin has also been tested in combination with rimantadine for antiviral activity against A and B type influenza.[10] Drotaverin has an adverse effects frequency of 0.9%, side effects being relatively uncommon.[11]

Drotaverine in sold under brand name No-Spa (Chinoin Pharmaceutical and Chemical Works, Hungary, a member of the Sanofi-Aventis).[citation needed]

References

Cite error: Invalid <references> tag; parameter "group" is allowed only.

Use <references />, or <references group="..." />


pl:Drotaweryna ru:Дротаверин
  1. Jump up Stepaniuk AG, Stepaniuk NG, Stoliarchuk AA, Stepaniuk GI, Chernobrovyĭ VN (1998). "[The characteristics of the analgesic action of nitrosorbide and no-shpa]". Eksperimental'naia I Klinicheskaia Farmakologiia (in Russian). 61 (4): 17–9. PMID 9783101. 
  2. Jump up Bolaji OO, Onyeji CO, Ogundaini AO, Olugbade TA, Ogunbona FA (1996). "Pharmacokinetics and bioavailability of drotaverine in humans". European Journal of Drug Metabolism and Pharmacokinetics. 21 (3): 217–21. doi:10.1007/BF03189716. PMID 8980918. 
  3. Jump up Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
  4. Jump up Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
  5. Jump up Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
  6. Jump up Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
  7. Jump up Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
  8. Jump up Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
  9. Jump up Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
  10. Jump up Zhilinskaya IN, Konovalova NI, Kiselev OI, Ashmarin IP (2007). "No-Spa and Remantadin are the novel complex preparations that inhibit effectively reproduction of the avian influenza viruses". Doklady Biological Sciences. 414: 249–50. doi:10.1134/S0012496607030234. PMID 17668635. 
  11. Jump up Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.