Amrinone

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Amrinone
File:Amrinone.svg
Systematic (IUPAC) name
5-amino-3,4'-bipyridin-6(1H)-one
Clinical data
Pregnancy
category
  • US: C (Risk not ruled out)
Routes of
administration
Intravenous
Legal status
Legal status
Pharmacokinetic data
Bioavailability n/a
Protein binding 10 to 49%
Metabolism Hepatic
Biological half-life 5 to 8 hours
Excretion Renal (63%) and fecal (18%)
Identifiers
CAS Number 60719-84-8
ATC code C01CE01 (WHO)
PubChem CID 3698
ChemSpider 3570
Chemical data
Formula C10H9N3O
Molar mass 187.198 g/mol[[Script error: No such module "String".]]
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Amrinone (INN) or inamrinone (USAN, changed in 2000 to prevent confusion with amiodarone[1]), trade name Inocor, is a pyridine phosphodiesterase 3 inhibitor.[2]

Uses

It is used in the treatment of congestive heart failure.

It has been studied for use before coronary artery bypass surgery.[3]

Actions

Increases cardiac contractility, vasodilator. Acts by inhibiting the breakdown of both cAMP and cGMP by the phosphodiesterase (PDE3) enzyme.

Indications

Short-term management of severe CHF (not used long term because of increased mortality, probably due to heart failure).

Contraindications

Patients with history of hypersensitivity to the drug.

Precautions

May increase myocardial ischemia. Blood pressure, pulse, and EKG should be constantly monitored. Amrinone should only be diluted with normal saline or 1/2 normal saline; no dextrose solutions should be used. Furosemide should not be administered into an IV line delivering Amrinone.

Side effects

Thrombocytopenia, hepatotoxicity, arrhythmia, nausea, and vomiting.

Routes

IV bolus and infusion as described earlier.

Pediatric dosage

Safety in children has not been established.

References

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de:Amrinon

ja:アムリノン

uk:Амрінон
  1. "Amrinone Becomes Inamrinone". USP Quality Review. United States Pharmacopeia. 73. March 2000. 
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