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style="background: #F8EABA; text-align: center;" colspan="2" | Identifiers
CAS number 468-53-1
PubChem 193296
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style="background: #F8EABA; text-align: center;" colspan="2" | Properties
Molecular formula C17H23NO3
Molar mass 289.37 g mol−1
log P 1.1
style="background: #F8EABA; text-align: center;" colspan="2" | Supplementary data page
Structure and
n, εr, etc.
Phase behaviour
Solid, liquid, gas
Spectral data UV, IR, NMR, MS
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Mesembrine is an alkaloid present in Sceletium tortuosum.[1] Mesembrine acts as a serotonin reuptake inhibitor[2], as well as a PDE4 inhibitor.[3] Mesembrine may contribute to the antidepressant effects of kanna.


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fr:Mésembrine uk:Месембрін
  1. Smith M, Crouch N, Gericke N, Hirst M (1996). "Psychoactive constituents of the genus Sceletium N.E.Br. and other Mesembryanthemaceae: a review". Journal of Ethnopharmacology. 50 (3): 119–30. doi:10.1016/0378-8741(95)01342-3. PMID 8691846. 
  2. Gary I. Stafforda, Mikael E. Pedersenb, Johannes van Stadena, Anna K. Jäger (2008). "Review on plants with CNS-effects used in traditional South African medicine against mental diseases". Journal of Ethnopharmacology. 119 (3): 513–537. doi:10.1016/j.jep.2008.08.010. PMID 18775771. 
  3. Mesembrine - an inhibitor of PDE4 that follows structure-activity relationship to rolipram. [1]