|Systematic (IUPAC) name|
|Metabolism||Gastric and hepatic|
|Biological half-life||11 ± 5 hours|
|Excretion||Fecal and renal|
|ATC code||A03AE02 (WHO)|
|DrugBank||(wrong structure) APRD00096 (wrong structure)|
|Molar mass||301.39 g/mol[[Script error: No such module "String".]]|
|Script error: No such module "collapsible list".|
Tegaserod is a 5-HT4 agonist manufactured by Novartis and sold under the name Zelnorm for the management of irritable bowel syndrome and constipation. It was removed from the market. Before then, it was the only drug approved by the United States Food and Drug Administration to help relieve the abdominal discomfort, bloating and constipation associated with irritable bowel syndrome. Its use was also approved to treat chronic idiopathic constipation.
Mechanism of action
The drug functions as a motility stimulant, achieving its desired therapeutic effects through activation of the 5-HT4 receptors of the enteric nervous system in the gastrointestinal tract. It also stimulates gastrointestinal motility and the peristaltic reflex, and allegedly reduces abdominal pain. Additionally, tegaserod is a 5-HT2B receptor antagonist.
Withdrawal from market
On March 30, 2007, the U.S. Food and Drug Administration requested that Novartis withdraw Zelnorm from shelves. The FDA alleges a relationship between prescriptions of the drug and increased risks of heart attack or stroke. An analysis of data collected on over 18,000 patients demonstrated adverse cardiovascular events in 13 of 11,614 patients treated with Zelnorm (a rate of 0.11%) as compared with 1 of 7,031 patients treated with placebo (a rate of 0.01%). Novartis alleges all of the affected patients had preexisting cardiovascular disease or risk factors for such, and further alleges that no causal relationship between tegaserod use and cardiovascular events has been demonstrated. On the same day as the FDA announcement, Novartis Pharmaceuticals Canada announced that it was suspending marketing and sales of the drug in Canada in response to a request from Health Canada. Some manufacturers in India, such as Cipla, seem to still have generic Tegaserod available in their listings and some online merchants may be selling it. Large cohort study based on US health insurance database showed that tegaserod doesn't increase the risk of cardiovascular event.
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- "New Data for Zelnorm". Retrieved March 30, 2007.
- "FDA approves first treatment for women with irritable-bowel syndrome". Retrieved March 30, 2007.
- Rossi, S. (2004). Australian Medicines Handbook. Adelaide: Health Communication Network. ISBN ISBN 0-9578521-4-2 Check
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- "Constipation drug pulled at FDA request". Retrieved March 30, 2007.
- "Zelnorm" (PDF). Novartis. Retrieved 2007-03-30.
- "Novartis suspends Canadian marketing and sales of Zelnorm in response to request from [[Health Canada]]". Retrieved 2007-03-30. URL–wikilink conflict (help)
- Cipla - Product List
- "Tegaserod and the Risk of Cardiovascular Ischemic Events: An Observational Cohort Study". Retrieved March 3, 2010.