Epithelial sodium channel blocker

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An epithelial sodium channel blocker is a sodium channel blocker which is selective for the epithelial sodium channel.

An example is amiloride, which is used in the treatment of hypertension.[1]


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  1. Sagnella GA, Swift PA (2006). "The renal epithelial sodium channel: genetic heterogeneity and implications for the treatment of high blood pressure". Curr. Pharm. Des. 12 (18): 2221–34. doi:10.2174/138161206777585157. PMID 16787251.