|Systematic (IUPAC) name|
|Biological half-life||5.8 to 8.2 hours|
|Excretion||renal (1/3) and biliary (2/3)|
|ATC code||C03BA10 (WHO)|
|Molar mass||354.80 g/mol[[Script error: No such module "String".]]|
Mechanism of action
Like the structurally related thiazide diuretics, xipamide acts on the kidneys to reduce sodium reabsorption in the distal convoluted tubule. This increases the osmolarity in the lumen, causing less water to be reabsorbed by the collecting ducts. This leads to increased urinary output. Unlike the thiazides, xipamide reaches its target from the peritubular side (blood side).
Additionally, it increases the secretion of potassium in the distal tubule and collecting ducts. In high doses it also inhibits the enzyme carbonic anhydrase which leads to increased secretion of bicarbonate and alkalizes the urine.
- cardiac oedema caused by decompensation of heart failure
- renal oedema, chronic renal disease (but not with anuria)
- hepatic oedema caused by cirrhosis
- hypertension in combination with chronic renal disease
After oral administration, 20 mg of xipamide are resorbed quickly and reach the peak plasma concentration of 3 mg/l within an hour. The diuretic effect starts about an hour after administration, reaches it speak between the third and sixth hour, and lasts for nearly 24 hours.
One third of the dose is glucuronidized, the rest is excreted directly through the kidney (1/3) and the faeces (2/3). The total plasma clearance is 30-40 ml/min. Xipamide can be filtrated by haemodialysis but not by peritoneal dialysis.
Initially 40 mg, it can be reduced to 10-20 mg to prevent a relapse.
The lowest effective dose is 5 mg. More than 60 mg have no additional effects.
- more than 1/10 of all patients
- 1/100 to 1/10
- 1/1000 to 1/10,000
- allergic reactions of the skin
- less than 1/10,000
- praecoma and coma hepaticum
- hypovolemia, hyponatremia, hypokalemia
- sulfonamide hypersensitivity
- pregnancy, lactation period
Not recommended combinations
- Xipamide lowers the renal clearance of lithium which can lead to lithium intoxication. (This interaction is classified as medium.)
Combinations requiring special precautions
The product information requests special precautions for these combinations:
- The antihypertensive effect can be increased by ACE inhibitors, barbiturates, phenothiazines, tricyclic antidepressants, alcohol, etc. (Classified as minor.)
- NSAIDs can reduce the antihypertensive and diuretic effects. Xipamide increases the neurotoxicity of high doses of salicylates. (Classified as minor.)
- Toxicity of cardiac glycosides is increased due to hypokalemia and hypomagnesemia.(Classified as minor.)
- Antiarrhythmic agents (classes Ia and III), phenothiazines and other antipsychotics increase the risk of torsade de pointes due to hypokalemia.
Interactions not included in the product information
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- Jasek, W, ed. (2007). Austria-Codex (in German). 1 (2007/2008 ed.). Vienna: Österreichischer Apothekerverlag. pp. 600–603. ISBN 3-85200-181-4 Check
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- Dinnendahl, V, Fricke, U, ed. (2007). Arzneistoff-Profile (in German). 10 (21 ed.). Eschborn, Germany: Govi Pharmazeutischer Verlag. ISBN 978-3-7741-98-46-3.
- Klopp, T, ed. (2007). Arzneimittel-Interaktionen (in German) (2007/2008 ed.). Arbeitsgemeinschaft für Pharmazeutische Information. ISBN 978-3-85200-184-5.