From Self-sufficiency
Jump to: navigation, search
Systematic (IUPAC) name
Clinical data
  • B (D if used to treat pregnancy-induced hypertension)
Routes of
Oral (capsules, tablets, oral solution)
Legal status
Legal status
  • ℞ (Prescription only)
Pharmacokinetic data
Bioavailability Variably absorbed from GI tract
Excretion Primarily excreted unchanged in urine
CAS Number 133-67-5
ATC code C03AA03 (WHO)
PubChem CID 5560
Chemical data
Formula C8H8Cl3N3O4S2
Molar mass 380.6558 g/mol[[Script error: No such module "String".]]
Script error: No such module "TemplatePar".Expression error: Unexpected < operator.

Trichlormethiazide (INN, currently being sold under the brand names of Achletin, Diu-Hydrin and Triflumen) is a diuretic with properties similar to those of hydrochlorothiazide.[1] It is usually administered for the treatment of oedema (including that which is associated with heart failure, hepatic cirrhosis and corticosteroid therapy) and hypertension.[1] In veterinary medicine, trichlormethiazide can be combined with dexamethasone to be used on horses with mild swelling of distal limbs and general bruising.[2]


As a diuretic (in particular a thiazide), trichlormethiazide encourages water loss from the body.[1] Trichlormethiazide works by inhibiting Na+/Cl- ion reabsorption from the distal tubules of the kidneys.[1] In addition, Trichlormethiazide increases the excretion of potassium.[1]


Trichlormethiazide appears to block the active reabsorption of chloride and possibly sodium in the ascending loop of Henle. This results in excretion of sodium, chloride and water, and thus acts as a diuretic.[1] Although Trichlormethiazide is used to treat hypertension, it's hypotensive effects may aren't necessarily due to their role as a diuretic.[1] Thiazides in general cause vasodilation by activating calcium-activated potassium channels in vascular smooth muscles and inhibiting various carbonic anhydrases in vascular tissue.[1]


Cite error: Invalid <references> tag; parameter "group" is allowed only.

Use <references />, or <references group="..." />
es:Triclormetiazida sr:Trihlormetiazid
  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 "DrugBank: DB01021 (Trichlormethiazide)". DrugBank. Retrieved 2008-01-23. 
  2. "Trichlormethiazide and Dexamethasone for veterinary use". Wedgewood Pharmacy. Retrieved 2008-01-24.