Torasemide

Torasemide

File:Torasemide.svg
Systematic (IUPAC) name
N-[(isopropylamino)carbonyl]-4-[(3-methylphenyl)amino]pyridine-3-sulfonamide
Clinical data
Pregnancy category	US: C (Risk not ruled out)
Routes of administration	Oral, IV
Legal status
Legal status	US: ℞-only
Pharmacokinetic data
Bioavailability	80-90%
Protein binding	Highly bound (>99%).
Metabolism	Hepatic (80%)
Biological half-life	3.5 hours; Cirrhosis: 7-8 hours
Identifiers
CAS Number	56211-40-6
ATC code	C03CA04 (WHO)
PubChem	CID 41781
DrugBank	APRD00217
Chemical data
Formula	C16H20N4O3S
Molar mass	348.421 g/mol[[]]
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Torasemide (rINN) or torsemide (USAN) is a pyridine-sulfonyl urea type loop diuretic mainly used in the management of edema associated with congestive heart failure. It is also used at low doses for the management of hypertension. It is marketed under the brand name Demadex.

Compared to other loop diuretics, torasemide has a more prolonged diuretic effect than equipotent doses of furosemide and relatively decreased potassium-loss. There is no evidence of torasemide-induced ototoxicity demonstrated in humans .

References

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External links

• Medlineplus drug information: Torsemide (Systemic) – information from USP DI Advice for the Patient

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