|Systematic (IUPAC) name|
|Topical (eye drops)|
|ATC code||S01HA04 (WHO)|
|Molar mass||294.389 g/mol[[Script error: No such module "String".]]|
Proxymetacaine (INN) or proparacaine (USAN), trade names Alcaine, Ak-Taine, and others, is a topical anesthetic drug of the amino ester group. It is indicated for use as an ophthalmic anesthetic (as eye drops) to reduce pain and discomfort during procedures involving the eye. Proxymetacaine is available as its hydrochloride salt in ophthalmic solutions at a concentration of 0.5%.
Mechanism of action
Proxymetacaine is believed to act as an antagonist on voltage-gated sodium channels to affect the permeability of neuronal membranes; how this inhibits pain sensations and the exact mechanism of action of proxymetacaine are, however, unknown.
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