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Dimethocaine, also known as larocaine, is a local anesthetic with stimulant properties that some studies show to be nearly as potent as cocaine. However, anecdotal user reports indicate no euphoria and only mild stimulating effects. Other users fail to perceive of any recreational effects whatsoever. The drug however still presents strain on the cardiovascular systems, like cocaine, with the potential to induce tachycardia which could be problematic for those who continuously redose. Additional reports of respiratory arrest have been noted.
Percent inhibition of 50 nM [3H]dopamine uptake in striatal synaptosomes at 0.1-100 uM compound concentration
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- Rigon AR, Takahashi RN. Stimulant activities of dimethocaine in mice: reinforcing and anxiogenic effects. Psychopharmacology (Berlin). 1996 Oct;127(4):323-7. PMID 8923567
- Wilcox KM, Kimmel HL, Lindsey KP, Votaw JR, Goodman MM, Howell LL. In vivo comparison of the reinforcing and dopamine transporter effects of local anesthetics in rhesus monkeys. Synapse. 2005 Dec 15;58(4):220-8. PMID 16206183 PDF
- Drugs Forum. "Dimethocaine".
- Brandt, S. D.; Sumnall, H. R.; Measham, F.; Cole, J. (2010). "The confusing case of NRG-1". BMJ. 341: c3564. doi:10.1136/bmj.c3564. PMID 20605894.