Difference between revisions of "Torasemide"

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Torasemide
File:Torasemide.svg
Systematic (IUPAC) name
N-[(isopropylamino)carbonyl]-4-[(3-methylphenyl)amino]pyridine-3-sulfonamide
Clinical data
Pregnancy
category
  • US: C (Risk not ruled out)
Routes of
administration		 Oral, IV
Legal status
Legal status
Pharmacokinetic data
Bioavailability 80-90%
Protein binding Highly bound (>99%).
Metabolism Hepatic (80%)
Biological half-life 3.5 hours; Cirrhosis: 7-8 hours
Identifiers
CAS Number 56211-40-6
ATC code C03CA04 (WHO)
PubChem CID 41781
DrugBank APRD00217
Chemical data
Formula C16H20N4O3S
Molar mass 348.421 g/mol[[Script error: No such module "String".]]
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Torasemide (rINN) or torsemide (USAN) is a pyridine-sulfonyl urea type loop diuretic mainly used in the management of edema associated with congestive heart failure. It is also used at low doses for the management of hypertension. It is marketed under the brand name Demadex.

Compared to other loop diuretics, torasemide has a more prolonged diuretic effect than equipotent doses of furosemide and relatively decreased potassium-loss. There is no evidence of torasemide-induced ototoxicity demonstrated in humans [1].

References

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External links

Sulfonamides
(except EA)
Furosemide# • Bumetanide • Torasemide • Etacrynic acid
Thiazide-likes (primarily DCT)
Potassium-sparing (at CD)
Osmotic diuretics (PT, DL)
VAs (DCT and CD)
Other


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de:Torasemid

es:Torasemida hr:Torasemid it:Torasemide ja:トラセミド pl:Torasemid

pt:Torasemida
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