Loxtidine

Loxtidine
	File:Loxtidine structure.png
Systematic (IUPAC) name
	[1-methyl-5-({3-[3-(piperidin-1-ylmethyl)phenoxy]propyl}amino)-1H-1,2,4-triazol-3-yl]methanol
Clinical data
Routes of; administration	Oral
Legal status
Legal status	Uncontrolled;
Identifiers
CAS Number	76956-02-0
ATC code	none
PubChem	CID 55473
ChemSpider	50093
Chemical data
Formula	C19H29N5O2
Molar mass	359.47 g/mol[[Script error: No such module "String".]]
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Loxtidine (INN), also known as lavoltidine (USAN, BAN) or AH-23,844, is a highly potent and selective H₂ receptor antagonist which was under development as a treatment for gastroesophageal reflux disease but was discontinued due to the discovery that it produced gastric carcinoid tumors in rodents.^[1]^[2]

Synthesis

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↑ Washington, Neena (1991). Antacids and anti-reflux agents. Boca Raton: CRC Press. ISBN 0-8493-5444-7.
↑ Dictionary of organic compounds. London: Chapman & Hall. 1996. ISBN 0-412-54090-8.
↑ Cliterow, J. W.; Bradshaw, J.; Price, B. J.; Martin-Smith, M.; Mackinon, J. W. M.; Judd, D. B.; Hayes, R.; Carey, L.; 1983, EP 0016565 .