|Systematic (IUPAC) name|
|Oral, Eye Drops|
|Biological half-life||12 Hours|
|ATC code||R06AX17 (WHO) S01|
|Molar mass||309.426 g/mol[[Script error: No such module "String".]]|
Ketotifen fumarate is a second-generation H1-antihistamine/mast cell stabilizer available in two forms. In its ophthalmic form, it is used to treat allergic conjunctivitis, or the itchy red eyes caused by allergies. In its oral form, it is used to prevent asthma attacks. Side effects include drowsiness, weight gain, dry mouth, irritability, and increased nosebleeds.
The drug is marketed as ophthalmic solutions under the brand names Zaditor/Zaditen (Novartis), Alaway (Bausch and Lomb), Zyrtec Itchy-Eye Drops, and Claritin Eye.
Ketotifen relieves and prevents eye itchiness and/or irritation associated with most seasonal allergies. It starts working within minutes after administering the drops. The drug has not been studied in children under three. The mean elimination half life is 12 hours. Besides its anti-histaminic activity, it is also a functional leukotriene antagonist and a phosphodiesterase inhibitor.
Ketotifen is used to up-regulate beta-2 adrenergic receptors down-regulated by beta-2 adrenergic agonists. It upregulates adrenergic receptors due to its phosphodiesterase inhibition, since a phosphodiesterase enzyme is involved in their feedback/homeostatic pathway.
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