Phenazone
From Self-sufficiency
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Systematic (IUPAC) name | |
---|---|
1,2-dihydro- 1,5-dimethyl- 2-phenyl- 3H-pyrazol- 3-one | |
Identifiers | |
CAS Number | 60-80-0 |
ATC code | N02BB01 (WHO) S02DA03 |
PubChem | CID 2206 |
DrugBank | DB01435 |
ChemSpider | 2121 |
Synonyms | analgesine, antipyrine |
Chemical data | |
Formula | C11H12N2O |
Molar mass | 188.226 g/mol[[Script error: No such module "String".]] |
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Phenazone (INN), phenazon, antipyrine (USAN), or analgesine is an analgesic and antipyretic. It was first synthesized by Ludwig Knorr in 1883.[1] It is formed by reducing diortho- dinitrodiphenyl with sodium amalgam and methyl alcohol, or by heating diphenylene-ortho-dihydrazine with hydrochloric acid to 150 °C. It crystallizes in needles which melt at 156 °C. Potassium permanganate oxidizes it to pyridazine tetracarboxylic acid.
Adverse effects
Possible adverse effects include:[citation needed]
- Allergy to pyrazolones
- Nausea
- Agranulocytosis
- Hepatotoxicity
See also
- Propyphenazone
- A/B Otic Drops, ear drops combined with benzocaine to relieve pain and remove cerumen
References
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40px | This analgesic-related article is a stub. You can help ssf by expanding it. |
es:Fenazona fr:Phénazone it:Fenazone nl:Antipyrine ja:アンチピリン pl:Fenazon ru:Феназон fi:Antipyriini
tr:Antipirin- ↑ Brune, K (1997). "The early history of non-opioid analgesics". Acute Pain. 1: 33. doi:10.1016/S1366-0071(97)80033-2.
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