Propacetamol
From Self-sufficiency
| File:Propacetamol-2d-skeletal.png | |
| Systematic (IUPAC) name | |
|---|---|
|
4-(acetamido)phenyl N,N-diethylglycinate | |
| Clinical data | |
| Routes of administration | IV[1][2] |
| Pharmacokinetic data | |
| Biological half-life | 2.4 hours [1] |
| Excretion | Renal |
| Identifiers | |
| CAS Number | 66532-85-2 |
| ATC code | N02BE05 (WHO) |
| PubChem | CID 68865 |
| Chemical data | |
| Formula | C14H2N2O3 |
| Molar mass | 264.3202 g/mol[[Script error: No such module "String".]] |
Propacetamol is a prodrug form of paracetamol which is formed from esterification of paracetamol, and the carboxylic acid Diethylglycin. This has the advantage of making it more water soluble. It is used in post-operative care and is delivered by I.V..[2] It is given if the patient is unable to take oral or rectally delivered paracetamol and non-steroidal anti-inflammatory drugs are contraindicated. The onset of analgaesia from propacetamol is more rapid than paracetamol given orally.[3] 2g of propacetamol are equivalent to 1g of paracetamol.[4]
See also
References
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- ↑ 1.0 1.1 Bannwarth B, Netter P, Lapicque F, Gillet P, Péré P, Boccard E, Royer RJ, Gaucher A (1992). "Plasma and cerebrospinal fluid concentrations of paracetamol after a single intravenous dose of propacetamol". Br J Clin Pharmacol. 34 (1): 79–81. PMC 1381380 Freely accessible. PMID 1633071.
- ↑ 2.0 2.1 Binhas M, Decailliot F, Rezaiguia-Delclaux S, Suen P, Dumerat M, François V, Combes X, Duvaldestin P (2004). "Comparative effect of intraoperative propacetamol versus placebo on morphine consumption after elective reduction mammoplasty under remifentanil-based anesthesia: a randomized control trial [ISRCTN71723173]". BMC Anesthesiol. 4 (1): 6. doi:10.1186/1471-2253-4-6. PMC 520811 Freely accessible. PMID 15367329. Retrieved 2008-04-01.
- ↑ Moller PL, Sindet-Pedersen S, Petersen CT, Juhl GI, Dillenschneider A, Skoglund LA (2005). "Onset of acetaminophen analgesia: comparison of oral and intravenous routes after third molar surgery". Br J Anaesth. 94 (5): 642–8. doi:10.1093/bja/aei109. PMID 15790675. Retrieved 2008-04-04.
- ↑ Flouvat B, Leneveu A, Fitoussi S, Delhotal-Landes B, Gendron A (2004). "Bioequivalence study comparing a new paracetamol solution for injection and propacetamol after single intravenous infusion in healthy subjects". Int J Clin Pharmacol Ther. 42 (1): 50–7. PMID 14756388.
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