Fenoprofen
File:Fenoprofen.png | |
Systematic (IUPAC) name | |
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2-(3-phenoxyphenyl)propanoic acid | |
Clinical data | |
Pregnancy category |
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Routes of administration | Oral |
Legal status | |
Legal status |
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Pharmacokinetic data | |
Metabolism | Major urinary metabolites are fenoprofen glucuronide and 4′-hydroxyfenoprofen glucuronide. |
Biological half-life | 3 hours |
Excretion | Renal (~90%) |
Identifiers | |
CAS Number | 29679-58-1 |
ATC code | M01AE04 (WHO) |
PubChem | CID 3342 |
Chemical data | |
Formula | C15H14O3 |
Molar mass | 242.26986 g/mol[[Script error: No such module "String".]] |
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Fenoprofen is a non-steroidal anti-inflammatory drug. Fenoprofen calcium is used for symptomatic relief for rheumatoid arthritis, osteoarthritis, and mild to moderate pain. Fenoprofen is marketed in the USA as Nalfon.
Contents
[hide]Pharmacology
Decreases inflammation, pain, and fever, probably through inhibition of cyclooxygenase activity and prostaglandin synthesis.
Contraindications
History of significantly impaired renal function; patients with known hypersensitivity to any component of the product; patients who have experienced asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs; treatment of perioperative pain in the setting of coronary artery bypass graft (CABG) surgery.
Drug Interactions
Aminoglycosides (eg, gentamicin): Plasma aminoglycoside levels may be elevated.
Angiotensin-converting enzyme (ACE) inhibitors: Antihypertensive effect of ACE inhibitors may be diminished.
Anticoagulants: Coadministration may prolong prothrombin time.
Aspirin: Fenoprofen Cl may be increased; coadministration is not recommended.
Diuretics: Patients treated with fenoprofen may be resistant to the effects of loop diuretics and thiazides.
Hydantoins, sulfonamides, sulfonylureas: Fenoprofen may displace these drugs from their binding site.
Lithium: Renal Cl of lithium may be reduced and plasma levels may be elevated, which may increase the risk of lithium toxicity.
Methotrexate: May increase methotrexate levels.
Phenobarbital: May decrease fenoprofen t ½ . Dosage adjustments of fenoprofen may be required if phenobarbital is added or withdrawn.
SSRIs (eg, fluoxetine, citalopram): The risk of GI effects may be increased.
Laboratory Test Interactions
False elevation in free and total serum T 3 as measured by Amerlex-M kit.
Brand names
- UK - Fenopron (Typharm Limited)
References
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Fenoprofen info from Drugs.com
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