Piroxicam
| 250px | |
| Systematic (IUPAC) name | |
|---|---|
|
(8E)-8-[hydroxy-(pyridin-2-ylamino)methylidene]- 9-methyl-10,10-dioxo-10λ6-thia-9-azabicyclo[4.4.0] deca-1,3,5-trien-7-one | |
| Clinical data | |
| Pregnancy category |
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| Routes of administration | PO |
| Legal status | |
| Legal status |
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| Pharmacokinetic data | |
| Metabolism | 4 to 10% renal |
| Biological half-life | 30 to 86 hours |
| Excretion | 4 to 10% renal |
| Identifiers | |
| CAS Number | 36322-90-4 |
| ATC code | M01AC01 (WHO) M02AA07, S01BC06 |
| PubChem | CID 5280452 |
| DrugBank | APRD01187 |
| ChemSpider | 10442653 |
| Chemical data | |
| Formula | C15H13N3O4S |
| Molar mass | 331.348 g/mol[[Script error: No such module "String".]] |
| (verify) | |
Piroxicam is a non-steroidal anti-inflammatory drug used to relieve the symptoms of rheumatoid and osteoarthritis, primary dysmenorrhoea, postoperative pain; and act as an analgesic, especially where there is an inflammatory component. It is manufactured by Pfizer under the tradename Feldene, and is available in the 
United Kingdom, Spain, 
Australia, 23x15px Italy and 
United States. It is also manufactured by Bosnalijek under the tradename Roxam, and is available in Eastern Europe, Africa, and the Middle East.
It is also used in veterinary medicine to treat certain neoplasias expressing cyclooxygenase (COX) receptors, such as bladder, colon, and prostate cancers.
Other brand names for Piroxicam include "Brexidol", "Brexin", "Erazon", "Exipan", "Faxiden", "Felden", "Feldoral", "Flamexin", "Hotemin", "Mobilis", "Pirox von ct", "Proponol", "Reumador", "Roxam", "Sinartrol", "Tracam", "Veral" and "Vurdon".
Mechanism of action
Piroxicam is an NSAID and, as such, is a non-selective COX inhibitor possessing both analgesic and antipyretic properties. It undergoes enterohepatic circulation.
Adverse effects
Piroxicam use can result in gastrointestinal toxicity, tinnitus, dizziness, headache, rash, and pruritus. The most severe adverse reactions are peptic ulceration, gastrointestinal bleeding, and severe skin reactions including Stevens-Johnson syndrome and toxic epidermal necrolysis. Approximately 30% of all patients receiving daily doses of 20 mg of piroxicam experience side effects.[1]
Piroxicam may cause skin to become more sensitive to sunlight.[2] Avoidance of sunlight and use of sunscreen is recommended.[citation needed]
Footnotes
- ↑ New Zealand Medicines and Medical Devices Safety Authority. "Candyl Medicines datasheet". Retrieved 2006-09-10.
- ↑ Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
de:Piroxicam es:Piroxicam fr:Piroxicam it:Piroxicam he:פירוקסיקאם hu:Piroxikám nl:Piroxicam ja:ピロキシカム pl:Piroksykam pt:Piroxicam ro:Piroxicam ru:Пироксикам th:ไพรอกซิแคม tr:Piroksikam
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- Non-steroidal anti-inflammatory drugs
- Pyridines
- Amides
- Benzothiazines
