Clobenpropit

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Clobenpropit
File:Clobenpropit.svg
Systematic (IUPAC) name
N'-[(4-chlorophenyl)methyl]-1-[3-(3H-imidazol-4-yl)propylsulfanyl]formamidine
Identifiers
CAS Number 145231-45-4
ATC code none
PubChem CID 2790
IUPHAR/BPS 1223
ChemSpider 2688
Chemical data
Formula C14H17ClN4S
Molar mass 308.83 g/mol[[Script error: No such module "String".]]
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Clobenpropit is a histamine H3 receptor antagonist.[1] It has neuroprotective effects via stimulation of GABA release in the brain.[2]

See also

References

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pt:Clobenpropit
  1. ↑ Sahlholm K, Nilsson J, Marcellino D, Fuxe K, Arhem P (2007). "The human histamine H3 receptor couples to GIRK channels in Xenopus oocytes". Eur. J. Pharmacol. 567 (3): 206–10. doi:10.1016/j.ejphar.2007.04.032. PMID 17537431. 
  2. ↑ Dai H, Fu Q, Shen Y, Hu W, Zhang Z, Timmerman H, Leurs R, Chen Z. The histamine H3 receptor antagonist clobenpropit enhances GABA release to protect against NMDA-induced excitotoxicity through the cAMP/protein kinase A pathway in cultured cortical neurons. European Journal of Pharmacology. 2007 Jun 1;563(1-3):117-23. PMID 17350613
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