JNJ-5207852
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| JNJ-5207852 | |
|---|---|
| File:JNJ5207852 structure.png | |
| 1-{3-[4-(Piperidin-1-ylmethyl)phenoxy]propyl}piperidine | |
| 1-({4-[3-(Piperidin-1-yl)propoxy]phenyl}methyl)piperidine | |
| style="background: #F8EABA; text-align: center;" colspan="2" | Identifiers | |
| Abbreviations | JNJ-5207852 |
| PubChem | 2766326 
|
| ChemSpider | 2046959
|
| MeSH | JNJ-5207852 |
| ChEBI | 312531 |
| SMILES | Script error: No such module "collapsible list". |
| InChI | Script error: No such module "collapsible list". |
| InChI key | PTKHFRNHJULJKT-UHFFFAOYSA-N |
| style="background: #F8EABA; text-align: center;" colspan="2" | Properties | |
| Molecular formula | C20H32N2O |
| Molar mass | 316.480 g/mol |
| Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) | |
| Infobox references | |
JNJ-5207852 is a histamine antagonist selective for the H3 subtype. It has stimulant and nootropic effects in animal studies,[1] and has been suggested as a possible treatment for memory defects associated with epilepsy.[2] JNJ-5207852 itself did not progress to clinical development due to poor pharmacokinetic characteristics, but the related compound JNJ-17216498 is currently in Phase II clinical trials for the treatment of narcolepsy.[3]
References
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- ↑ Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
- ↑ Jia F, Kato M, Dai H, Xu A, Okuda T, Sakurai E, Okamura N, Lovenberg TW, Barbier A, Carruthers NI, Iinuma K, Yanai K. Effects of histamine H(3) antagonists and donepezil on learning and mnemonic deficits induced by pentylenetetrazol kindling in weanling mice. Neuropharmacology. 2006 Mar;50(4):404-11. PMID 16310812
- ↑ Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
