Fenoldopam

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Fenoldopam
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Systematic (IUPAC) name
(RS)-6-chloro-1-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol
Clinical data
Pregnancy
category
  • B
Routes of
administration
IV
Pharmacokinetic data
Metabolism Hepatic (CYP not involved)
Biological half-life 5 minutes
Excretion Renal (90%) and fecal (10%)
Identifiers
CAS Number 67227-57-0
ATC code C01CA19 (WHO)
PubChem CID 3341
DrugBank APRD00969
ChemSpider 3224
Chemical data
Formula C16H16ClNO3
Molar mass 305.76 g/mol
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Fenoldopam (Corlopam) is a drug and synthetic benzazepine derivative which acts as a peripheral selective D1 receptor weak partial agonist/antagonist and is used as an antihypertensive.[1]

Indications

Fenoldopam is used as an antihypertensive agent postoperatively, and also via IV to treat hypertensive crisis.[2]

Pharmacology

By activating peripheral D1 receptors, fenoldopam causes arterial/arteriolar vasodilation leading to a decrease in blood pressure. It is particularly effective in dilating the renal, mesenteric, and coronary arteries, where D1.receptors are found.[2] It decreases afterload and also through specific dopamine receptors along the nephron promoting sodium excretion.[citation needed]

Side effects

Adverse effects include headache, flushing, angina, hypotension, reflex tachycardia, and increased intraocular pressure.[2]

Contraindications

Contraindicated with patients who suffers from glaucoma.

References

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  2. 2.0 2.1 2.2 Shen, Howard (2008). Illustrated Pharmacology Memory Cards: PharMnemonics. Minireview. p. 9. ISBN 1-59541-101-1.