Difference between revisions of "Mometasone furoate"

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Mometasone furoate
File:Mometasone furoate.png
Systematic (IUPAC) name
(11β,16α)-9,21-dichloro-11-hydroxy-16-methyl-3,20-dioxopregna-1,4-dien-17-yl 2-furoate
Clinical data
Pregnancy
category
  • US: C (Risk not ruled out)
Routes of
administration		 topical, nasal
Legal status
Legal status
  • Rx Only (US)
Pharmacokinetic data
Bioavailability Nasal spray is virtually undetectable in plasma; but systemic availability is comparable to fluticasone.[1]
Protein binding 98% to 99%
Metabolism hepatic
Biological half-life 5.8 hours
Identifiers
CAS Number 105102-22-5 83919-23-7 as Furoate
ATC code D07AC13 (WHO) D07XC03, R01AD09, R03BA07
PubChem CID 123620
DrugBank APRD00289
Synonyms (9R,10S,11S,13S,14S,16R,17R)-9-chloro-17-(2-chloroacetyl)-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl furan-2-carboxylate
Chemical data
Formula C22H28Cl2O4 for Mometasone
C27H30O6Cl2 as Furoate
Molar mass 427.361 g/mol (Mometasone)
521.4 g/mol (Furoate)
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Mometasone furoate (also referred to as mometasone) is a glucocorticoid steroid used topically to reduce inflammation of the skin or in the airways.

Uses, administration, and pharmacodynamics

File:Momate.jpg

Mometasone furoate is used in the treatment of inflammatory skin disorders (such as eczema and psoriasis), allergic rhinitis (such as hay fever), asthma[2][3] for patients unresponsive to less potent corticosteroids, and penile phimosis [4]. In terms of steroid strength, it is more potent than hydrocortisone, and less potent than dexamethasone.[citation needed]

It reduces inflammation by causing several effects:[5][6]

  • reversing the activation of inflammatory genes
  • activating the secretion of anti-inflammatory proteins
  • stabilising cell membranes
  • decreasing the influx of inflammatory cells

Availability

Schering-Plough markets the medication under the following brand names; Elocon (Elocom, Elomet) as a cream or ointment for skin conditions, Nasonex as a nasal spray for upper respiratory conditions such as nasal sinus inflammation, Asmanex Twisthaler as a dry powder inhaler (DPI) for lower respiratory conditions. Essex pharma markets the medication under the brand name Ecural.

It is also available as a veterinary drug in an otic (ears) form for treatment of otitis externa under the brand name Mometamax.[7]

References

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External links

Mineralocorticoids
(3-one, 4-ene,
no FG at 16)
Glucocorticoids
(3-one, 4-ene,
11-FG,
17-hydroxy)
Pregnenedione
(+20-one)
Pregnadienediol
(+21-hydroxy)
Prednisone (Meprednisone) · HALOGENATED AT 9: Fluorometholone · HALOGENATED, WITH FG AT 16: Fluocortolone (Clocortolone, Diflucortolone, Fluocortin) · Desoximetasone
Pregnadienetriol
(+11-hydroxy)
Pregnatriene
(+2-ene)
Other/ungrouped
HALOGENATED: Loteprednol · HALOGENATED, WITH FG AT 16: Fludroxycortide · Formocortal · Mometasone furoate
Aldosterone antagonists
Synthesis modifiers
Decongestants and other nasal preparations (R01)
Topical
Antiallergic agents,
excluding corticosteroids
Beclometasone • Prednisolone • Dexamethasone • Flunisolide • Budesonide • Betamethasone • Tixocortol • Fluticasone • Mometasone furoate • Triamcinolone • Ciclesonide
Other nasal preparations
Systemic use:
Sympathomimetics

M: RES

anat(n, x, l, c)/phys/devp

proc, drug(R1/2/3/5/6/7)

hu:Mometazon-furoát

nl:Mometasonfuroaat pl:Mometazon pt:Mometasona

ru:Мометазона фуроат
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  5. ↑ Publishers, Jones and Bartlett (2009-07-15). "Nurse's Drug Handbook 2010". p. 677. ISBN 9780763779009. 
  6. ↑ Mani S. Kavuru (2007). "ch. 9 Anti-inflammatory agents". Diagnosis and Management of Asthma. ISBN 9781932610383. 
  7. ↑ "Mometamax". Intervet USA. Retrieved 19 June 2010. 
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