Estramustine

Estramustine
	File:Estramustine Structural Formulae.png
	File:Estramustine-3D-vdW.png
Systematic (IUPAC) name
	(17β)-17-hydroxyestra-1(10),2,4-trien-3-yl bis(2-chloroethyl)carbamate
Pharmacokinetic data
Biological half-life	20 hours
Identifiers
CAS Number	2998-57-4
ATC code	L01XX11 (WHO)
PubChem	CID 18140
DrugBank	APRD00625
Chemical data
Formula	C23H31Cl2NO3
Molar mass	440.403 g/mol[[Script error: No such module "String".]]
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Estramustine (Emcyt, Estracit) is a chemotherapy agent used to treat prostate cancer. It is a derivative of estrogen (specifically, estradiol) with a nitrogen mustard-carbamate ester moiety that makes it a alkylating antineoplastic agent similar to mechlorethamine, with estrogen-induced specificity.

Estramustine is marketed in the United States by Pharmacia (now a subsidiary of Pfizer)

Clinical uses

Estramustine is indicated for the palliative treatment of metastatic and/or progressive carcinoma of the prostate.

Fex, H. J.; Hogberg, K. B.; Konyves, I.; Kneip, O. J.; 1967, U.S. Patent 3,299,104.