Mometasone furoate

Mometasone furoate

File:Mometasone furoate.png
Systematic (IUPAC) name
(11β,16α)-9,21-dichloro-11-hydroxy-16-methyl-3,20-dioxopregna-1,4-dien-17-yl 2-furoate
Clinical data
Pregnancy category	US: C (Risk not ruled out)
Routes of administration	topical, nasal
Legal status
Legal status	Rx Only (US)
Pharmacokinetic data
Bioavailability	Nasal spray is virtually undetectable in plasma; but systemic availability is comparable to fluticasone.
Protein binding	98% to 99%
Metabolism	hepatic
Biological half-life	5.8 hours
Identifiers
CAS Number	105102-22-5 83919-23-7 as Furoate
ATC code	D07AC13 (WHO) D07XC03, R01AD09, R03BA07
PubChem	CID 123620
DrugBank	APRD00289
Synonyms	(9R,10S,11S,13S,14S,16R,17R)-9-chloro-17-(2-chloroacetyl)-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl furan-2-carboxylate
Chemical data
Formula	C22H28Cl2O4 for Mometasone C27H30O6Cl2 as Furoate
Molar mass	427.361 g/mol (Mometasone) 521.4 g/mol (Furoate)

Mometasone furoate (also referred to as mometasone) is a glucocorticoid steroid used topically to reduce inflammation of the skin or in the airways.

Uses, administration, and pharmacodynamics

File:Momate.jpg

Mometasone furoate is used in the treatment of inflammatory skin disorders (such as eczema and psoriasis), allergic rhinitis (such as hay fever), asthma for patients unresponsive to less potent corticosteroids, and penile phimosis . In terms of steroid strength, it is more potent than hydrocortisone, and less potent than dexamethasone.

It reduces inflammation by causing several effects:

• reversing the activation of inflammatory genes
• activating the secretion of anti-inflammatory proteins
• stabilising cell membranes
• decreasing the influx of inflammatory cells

Availability

Schering-Plough markets the medication under the following brand names; Elocon (Elocom, Elomet) as a cream or ointment for skin conditions, Nasonex as a nasal spray for upper respiratory conditions such as nasal sinus inflammation, Asmanex Twisthaler as a dry powder inhaler (DPI) for lower respiratory conditions. Essex pharma markets the medication under the brand name Ecural.

It is also available as a veterinary drug in an otic (ears) form for treatment of otitis externa under the brand name Mometamax.

External links

• Mometasone Furoate Oral Inhalation (MedlinePlus)
• Mometasone Furoate Nasal Inhalation (MedlinePlus)
• Nasonex Home page
• Asmanex Home page
• U.S. National Library of Medicine: Drug Information Portal - Mometasone furoate

hu:Mometazon-furoát ru:Мометазона фуроат