Biphenylindanone A
| 220px | |
| Systematic (IUPAC) name | |
|---|---|
|
3’-(((2-cyclopentyl-6,7-dimethyl-1-oxo-2,3-dihydro- 1H-inden-5-yl)oxy)methyl)biphenyl-4-carboxylic acid | |
| Identifiers | |
| ATC code | none |
| PubChem | CID 9868580 |
| Chemical data | |
| Formula | C30H30O4 |
| Molar mass | 454.556 g/mol[[Script error: No such module "String".]] |
| Script error: No such module "collapsible list". | |
Biphenylindanone A (BINA, LS-193,571) is a research agent which acts as a potent and selective positive allosteric modulator for the group II metabotropic glutamate receptor subtype mGluR2.
In animal studies it showed anxiolytic and antipsychotic effects,[1] and blocked the effects produced by the hallucinogenic drug DOB. BINA and other selective mGluR2 positive modulators have therefore been suggested as a novel class of drugs for the treatment of schizophrenia which may have superior properties to traditional antipsychotic drugs.[2]
BINA decreases cocaine self-administration in rats, with no effect on food self-administration, and is in regard to this discrimination superior to the mGluR2/3 agonist LY-379,268[3]
References
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- ↑ Galici R, Jones CK, Hemstapat K; et al. (2006). "Biphenyl-indanone A, a positive allosteric modulator of the metabotropic glutamate receptor subtype 2, has antipsychotic- and anxiolytic-like effects in mice". The Journal of pharmacology and experimental therapeutics. 318 (1): 173–85. doi:10.1124/jpet.106.102046. PMID 16608916.
- ↑ Benneyworth MA, Xiang Z, Smith RL, Garcia EE, Conn PJ, Sanders-Bush E (2007). "A selective positive allosteric modulator of metabotropic glutamate receptor subtype 2 blocks a hallucinogenic drug model of psychosis". Molecular pharmacology. 72 (2): 477–84. doi:10.1124/mol.107.035170. PMID 17526600.
- ↑ PMID 20555310
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