Indantadol

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Indantadol
File:Indantadol.svg
Systematic (IUPAC) name
N-(2,3-dihydro-1H-inden-2-yl)glycinamide
Clinical data
Routes of
administration
Oral
Legal status
Legal status
  • Uncontrolled
Identifiers
CAS Number 202844-10-
ATC code none
ChemSpider 16017060
Chemical data
Formula C11H14N2O
Molar mass 190.24 g/mol[[Script error: No such module "String".]]
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Indantadol (CHF-3381, V-3381) is a drug which was formerly being investigated as an anticonvulsant and neuroprotective and is now under development for the treatment of neuropathic pain and chronic cough in Europe by Vernalis and Chiesi.[1][2][3][4][5][6][7][8] It acts as a competitive, reversible, and non-selective monoamine oxidase inhibitor,[9][5][6] and as a low affinity, non-competitive NMDA receptor antagonist.[1][2][10] A pilot study of indantadol for chronic cough was initiated in October 2009 and in April 2010 it failed to achieve significant efficacy in neuropathic pain in phase IIb clinical trials.[11][8][12][7]

See also

References

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  5. 5.0 5.1 "CHF 3381". Drugs in R&D. 5 (1): 28–30. 2004. PMID 14725488. 
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  7. 7.0 7.1 "IN-STEP Phase IIb study results". 
  8. 8.0 8.1 "Vernalis initiates Pilot Study of V3381 in patients with chronic cough". 
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  11. "V3381CC". 
  12. "Vernalis completes recruitment in V3381 Phase II IN-STEP study for neuropathic pain".