Talampanel

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Talampanel
File:Talampanel skeletal.svg
Systematic (IUPAC) name
(8R)-7-Acetyl-5-(4-aminophenyl)-8,9-dihydro-8-methyl-7H-1,3-dioxolo[4,5-h] [2,3]benzodiazepine
Legal status
Legal status
  • investigational
Identifiers
CAS Number 161832-65-1
ATC code none
PubChem CID 164509
Chemical data
Formula C19H19N3O3
Molar mass 337.372 g/mol[[Script error: No such module "String".]]
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Talampanel (GYKI 53405) is a drug which is being investigated for the treatment of epilepsy[1], malignant gliomas[2] and amyotrophic lateral sclerosis (ALS)[3].

It is a noncompetitive antagonist of the AMPA receptor, a type of glutamate receptor in the central nervous system.[4]

References

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Benzodiazepine derivatives (N05BA, N05CD)
1,4-Benzodiazepines

Bromazepam · Camazepam · Carburazepam · Chlordiazepoxide · Cinolazepam · Clonazepam · Clorazepate · Cyprazepam · Delorazepam · Demoxepam · Devazepide* · Diazepam · Doxefazepam · Elfazepam · Ethyl carfluzepate · Ethyl dirazepate · Ethyl loflazepate · Fletazepam · Fludiazepam · Flunitrazepam · Flurazepam · Flutemazepam · Flutoprazepam · Fosazepam · Gidazepam · Halazepam · Iclazepam · Ketazolam · Lorazepam · Lormetazepam · Meclonazepam · Medazepam · Menitrazepam · Metaclazepam · Motrazepam · Nimetazepam · Nitrazepam · Nitrazepate · Nordazepam · Nortetrazepam · Oxazepam · Phenazepam · Pinazepam · Pivoxazepam · Prazepam · Proflazepam · Quazepam · QH-II-66 · Reclazepam · Ro5-2904 · Sulazepam · Temazepam · Tetrazepam · Tifluadom* · Tolufazepam · Tuclazepam · Uldazepam

1,5-Benzodiazepines
2,3-Benzodiazepines *

Girisopam · GYKI-52466 · GYKI-52895 · Nerisopam · Talampanel · Tofisopam

Triazolobenzodiazepines
Imidazobenzodiazepines
Oxazolobenzodiazepines
Thienodiazepines
Pyridodiazepines
Pyrazolodiazepines
Pyrrolodiazepines
Tetrahydroisoquinobenzodiazepines
Benzodiazepine prodrugs
 * atypical activity profile (not GABAA receptor ligands)


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  1. ↑ Luszczki, JJ (2009). "Third-generation antiepileptic drugs: mechanisms of action, pharmacokinetics and interactions". Pharmacological reports : PR. 61 (2): 197–216. PMID 19443931.  edit
  2. ↑ Iwamoto, F. M.; Kreisl, T. N.; Kim, L.; Duic, J. P.; Butman, J. A.; Albert, P. S.; Fine, H. A. (2010). "Phase 2 trial of talampanel, a glutamate receptor inhibitor, for adults with recurrent malignant gliomas". Cancer. 116 (7): NA. doi:10.1002/cncr.24957. PMC 2846997 Freely accessible. PMID 20143438.  edit
  3. ↑ Pascuzzi, R. M.; Shefner, J.; Chappell, A. S.; Bjerke, J. S.; Tamura, R.; Chaudhry, V.; Clawson, L.; Haas, L.; Rothstein, J. D. (2009). "A phase II trial of talampanel in subjects with amyotrophic lateral sclerosis". Amyotrophic Lateral Sclerosis. 11 (3): 091207182741053. doi:10.3109/17482960903307805. PMID 19961264.  edit
  4. ↑ Aujla, P. K.; Fetell, M. R.; Jensen, F. E. (2009). "Talampanel suppresses the acute and chronic effects of seizures in a rodent neonatal seizure model". Epilepsia. 50 (4): 694. doi:10.1111/j.1528-1167.2008.01947.x. PMC 2672962 Freely accessible. PMID 19220413.  edit
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