Quazinone

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Quazinone
File:Quazinone structure.png
Systematic (IUPAC) name
(3R)-6-chloro-3-methyl-5,10-dihydroimidazo[2,1-b]quinazolin-2(3H)-one
Clinical data
Routes of
administration		 Oral
Legal status
Legal status
  • ℞ (Prescription only)
Identifiers
CAS Number 70018-51-8
ATC code none
PubChem CID 6603980
ChemSpider 5036286
Synonyms Ro 13-6438
Chemical data
Formula C11H10ClN3O
Molar mass 235.67 g/mol[[Script error: No such module "String".]]
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Quazinone (Dozonone, Posicor) is a cardiotonic and vasodilator drug which was developed and marketed in the 1980s for the treatment of heart disease.[1][2][3][4][5] It acts as a selective PDE3 inhibitor.[6][7] It is no longer available.[1]

Synthesis

450px[8]

See also

References

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PDE1
PDE2
PDE3
Amrinone • Anagrelide • Bucladesine • Cilostamide • Cilostazol • Enoximone • KMUP-1 • Milrinone • Quazinone • RPL-554 • Siguazodan • Trequinsin • Vesnarinone • Zardaverine
PDE4
PDE5
PDE6
PDE7
PDE9
PDE10
Nonselective
Cardiac stimulants excluding cardiac glycosides (C01C)
Adrenergic and
dopaminergic agents
α
β
mixed
Both
Unknown/ungrouped
Phosphodiesterase inhibitors (PDE3I)
Other cardiac stimulants
  1. ↑ 1.0 1.1 David J. Triggle (1996). Dictionary of Pharmacological Agents. Boca Raton: Chapman & Hall/CRC. ISBN 0-412-46630-9. 
  2. ↑ Eigenmann R, Gerold M, Holck M (1984). "Cardiovascular profile of Ro 13-6438, a novel positive inotropic agent with vasodilating properties". Journal of Cardiovascular Pharmacology. 6 (3): 511–9. PMID 6202980. 
  3. ↑ Holck M, Thorens S, Muggli R, Eigenmann R (1984). "Studies on the mechanism of positive inotropic activity of Ro 13-6438, a structurally novel cardiotonic agent with vasodilating properties". Journal of Cardiovascular Pharmacology. 6 (3): 520–30. PMID 6202981. 
  4. ↑ Belz GG, Stern HC, Butzer R (1985). "Dose-response following single administrations of a new cardiac performance enhancer RO 13-6438 in normal volunteers". Journal of Cardiovascular Pharmacology. 7 (1): 86–90. PMID 2580156. 
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  7. ↑ Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
  8. ↑ Chodnekar, M. S.; Kaiser, A.; 1981, U.S. Patent 4,256,748
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