Difference between revisions of "Fluorometholone"

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Latest revision as of 16:48, 19 September 2010

Fluorometholone
Systematic (IUPAC) name
File:Fluorometholone.png
(1R,2S,8S,10S,11S,14R,15S,17S)-14-acetyl-1-fluoro-14,17-dihydroxy-2,8,15-trimethyltetracyclo[8.7.0.0^2,7.0^11,15]heptadeca-3,6-dien-5-one
Clinical data
Pregnancy category	C
Identifiers
CAS Number	426-13-1
ATC code	C05AA06 (WHO) D07AB06, D07XB04, D10AA01, S01BA07, S01CB05
PubChem	CID 9878
DrugBank	APRD00980
Synonyms	(6S,8S,9R,10S,11S,13S,14S,17R)-17-acetyl-9-fluoro-11,17-dihydroxy-6,10,13-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
Chemical data
Formula	C₂₂H₂₉FO₄
Molar mass	376.462 g/mol[[Script error: No such module "String".]]

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Fluorometholone is a corticosteroid, most often used after laser-based refractive surgery. It is marketed under the brand names FML (Allergan) and Flarex (Alcon).

Fluorometholone acetate ophthalmic suspension is indicated for use in the treatment of steroid responsive inflammatory conditions of the palpebral and bulbar conjunctiva, cornea, and anterior segment of the eye.

External links

Corticosteroids – glucocorticoid/receptor and mineralocorticoid/receptor
(A07EA, C05AA, D07, D10AA, H02, R01AD, R03BA, S01BA, S02B, and S03B) (Endogenous in CAPS)

Mineralocorticoids
(3-one, 4-ene,
no FG at 16)

Pregnenedione: ALDOSTERONE · 11-DEOXYCORTICOSTERONE · HALOGENATED AT 9: Fludrocortisone

Glucocorticoids
(3-one, 4-ene,
11-FG,
17-hydroxy)

Pregnene	CORTISONE
Pregnenedione (+20-one)	HYDROCORTISONE/CORTISOL^# (Hydrocortisone aceponate, Hydrocortisone buteprate, Hydrocortisone butyrate) · Budesonide · Ciclesonide · Deflazacort · Medrysone · Tixocortol · HALOGENATED AT 6: Cloprednol · HALOGENATED, WITH FG AT 16: Halcinonide
Pregnadiene (+1-ene)	Rimexolone · HALOGENATED, WITH FG AT 16: Flunisolide · Triamcinolone · Amcinonide · Fluocinolone acetonide (Fluocinonide)
Pregnadienediol (+21-hydroxy)	Prednisone (Meprednisone) · HALOGENATED AT 9: Fluorometholone · HALOGENATED, WITH FG AT 16: Fluocortolone (Clocortolone, Diflucortolone, Fluocortin) · Desoximetasone
Pregnadienetriol (+11-hydroxy)	Prednisolone^# (Methylprednisolone, Methylprednisolone aceponate, Prednicarbate, Prednylidene) · Desonide · HALOGENATED: Fluprednisolone (Difluprednate, Fluperolone) · HALOGENATED, WITH FG AT 16: Dexamethasone^# · Betamethasone (Clobetasol, Clobetasone, Diflorasone, Halometasone, Ulobetasol) · Beclometasone · Paramethasone · Alclometasone · Fluclorolone · Flumetasone · Fluprednidene
Pregnatriene (+2-ene)	Cortivazol
Androstene	HALOGENATED, WITH FG AT 16: Fluticasone (Fluticasone propionate, Fluticasone furoate)
Other/ungrouped	HALOGENATED: Loteprednol · HALOGENATED, WITH FG AT 16: Fludroxycortide · Formocortal · Mometasone furoate

Aldosterone antagonists

Spironolactone · Eplerenone · Potassium canrenoate · Canrenone

Synthesis modifiers

Trilostane · Carbenoxolone · Aminoglutethimide · Metyrapone

^#WHO-EM
^‡Withdrawn from market
Clinical trials:
- ^†Phase III
- ^§Never to phase III

Vasoprotectives (C05)

Antihemorrhoidals for topical use

corticosteroids (Hydrocortisone, Prednisolone, Betamethasone, Fluorometholone, Fluocortolone, Dexamethasone, Fluocinolone acetonide, Fluocinonide)

local anesthetics (Lidocaine, Tetracaine, Benzocaine, Cinchocaine, Procaine, Oxetacaine, Pramocaine)

other (Tribenoside)

Antivaricose therapy

heparins or heparinoids for topical use (Organo-heparinoid, Sodium apolate, Heparin, Pentosan polysulfate)

sclerosing agents for local injection (Monoethanolamine oleate, Polidocanol, Invert sugar, Sodium tetradecyl sulfate, Phenol)

other (Calcium dobesilate)

Capillary stabilising agents

bioflavonoids (Rutoside, Monoxerutin, Diosmin, Troxerutin, Hidrosmin) - other (Tribenoside)

M: VAS

anat(a:h,u,t,a,l,v:h,u,t,a,l)/phys/devp

noco/syva/cong/tumr, sysi/epon

proc, drug(C3,C4,C5,C9)

30px	This drug article relating to the cardiovascular system is a stub. You can help ssf by expanding it. v d e

40px	This dermatologic drug article is a stub. You can help ssf by expanding it. v d e

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Difference between revisions of "Fluorometholone"

Latest revision as of 16:48, 19 September 2010

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