JTE-907

From Self-sufficiency
Jump to: navigation, search
JTE-907
File:JTE-907.png
Systematic (IUPAC) name
N-(benzo[1,3]dioxol-5-ylmethyl)-7-methoxy-2-oxo-8-pentyloxy-1,2-dihydroquinoline-3-carboxamide
Chemical data
Formula C24H26N2O6
Molar mass 438.472[[Script error: No such module "String".]]
Script error: No such module "collapsible list".
Script error: No such module "TemplatePar".Expression error: Unexpected < operator.

JTE-907 is a drug used in scientific research which acts as a selective CB2 inverse agonist.[1][2] It has antiinflammatory effects in animal studies,[3] thought to be mediated by an interaction between the CB2 receptor and IgE.[4]

References

  1. ↑ Iwamura H, Suzuki H, Ueda Y, Kaya T, Inaba T. In vitro and in vivo pharmacological characterization of JTE-907, a novel selective ligand for cannabinoid CB2 receptor. Journal of Pharmacology and Experimental Therapeutics. 2001 Feb;296(2):420-5. PMID 11160626
  2. ↑ Raitio KH, Savinainen JR, Vepsäläinen J, Laitinen JT, Poso A, Järvinen T, Nevalainen T. Synthesis and SAR studies of 2-oxoquinoline derivatives as CB2 receptor inverse agonists. Journal of Medicinal Chemistry. 2006 Mar 23;49(6):2022-7. PMID 16539390
  3. ↑ Ueda Y, Miyagawa N, Matsui T, Kaya T, Iwamura H. Involvement of cannabinoid CB(2) receptor-mediated response and efficacy of cannabinoid CB(2) receptor inverse agonist, JTE-907, in cutaneous inflammation in mice. European Journal of Pharmacology. 2005 Sep 27;520(1-3):164-71. PMID 16153638
  4. ↑ Ueda Y, Miyagawa N, Wakitani K. Involvement of cannabinoid CB2 receptors in the IgE-mediated triphasic cutaneous reaction in mice. Life Sciences. 2007 Jan 9;80(5):414-9. PMID 17055000
40px This article about a cannabinoid is a stub. You can help ssf by expanding it.


Retrieved from "http://ssf.f15ijp.com/wiki/index.php?title=JTE-907&oldid=28673"