L-759,656
From Self-sufficiency
| 240px | |
| Systematic (IUPAC) name | |
|---|---|
|
(6aR,10aR)-1-methoxy-6,6-dimethyl-9-methylidene-3-(2-methyloctan-2-yl)-7,8,10,10a-tetrahydro-6aH-benzo[c]chromene | |
| Identifiers | |
| PubChem | CID 5311216 |
| IUPHAR/BPS | 749 |
| Chemical data | |
| Formula | C26H40O2 |
| Molar mass | 384.593 g/mol[[Script error: No such module "String".]] |
| Script error: No such module "collapsible list". | |
L-759,656 is an analgesic drug which is a cannabinoid agonist. It is a highly selective agonist for the CB2 receptor, with selectivity of 414x for CB2 over CB1,[1] although it is still not as selective as newer agents such as HU-308.
It produces some similar effects to other cannabinoid agonists such as analgesia, but with little or no sedative or psychoactive effects due to its weak CB1 activity, and a relatively strong antiinflammatory effect due to its strong activity at CB2.[2][3]
| 40px | This article about a cannabinoid is a stub. You can help ssf by expanding it. |
References
- ↑ Ross, R.; Brockie, H.; Stevenson, L.; Murphy, V.; Templeton, F.; Makriyannis, A.; Pertwee, R. (1999). "Agonist-inverse agonist characterization at CB1 and CB2 cannabinoid receptors of L759633, L759656, and AM630". British journal of pharmacology. 126 (3): 665–672. doi:10.1038/sj.bjp.0702351. PMC 1565857 Freely accessible. PMID 10188977. More than one of
|author2=and|last2=specified (help); More than one of|author3=and|last3=specified (help); More than one of|author4=and|last4=specified (help); More than one of|author5=and|last5=specified (help); More than one of|author6=and|last6=specified (help); More than one of|author7=and|last7=specified (help) - ↑ Huffman, JW (2000). "The search for selective ligands for the CB2 receptor". Current pharmaceutical design. 6 (13): 1323–37. doi:10.2174/1381612003399347. PMID 10903395.
- ↑ Huffman, JW (2005). "CB2 receptor ligands". Mini reviews in medicinal chemistry. 5 (7): 641–9. doi:10.2174/1389557054368844. PMID 16026310.
Categories:
- Pages with script errors
- Pages with broken file links
- Pages with citations having redundant parameters
- Infobox drug tracked parameters
- Chemical articles without CAS Registry Number
- Articles without EBI source
- Chemical pages without ChemSpiderID
- Chemical pages without DrugBank identifier
- Articles without KEGG source
- Articles without InChI source
- Articles without UNII source
- Drugboxes with an unspecified ATC code
- Drugs with no legal status
- Articles containing unverified chemical infoboxes
- Cannabinoid stubs
- Cannabinoids
- Benzochromenes
- Phenol ethers
- 2Fix
