L-759,633
From Self-sufficiency
| 240px | |
| Systematic (IUPAC) name | |
|---|---|
|
(6aR,10aR)-1-methoxy-6,6,9-trimethyl-3-(2-methyloctan-2-yl)-6a,7,10,10a-tetrahydrobenzo[c]chromene | |
| Identifiers | |
| PubChem | CID 5311215 |
| IUPHAR/BPS | 748 |
| Chemical data | |
| Formula | C26H40O2 |
| Molar mass | 384.593 g/mol[[Script error: No such module "String".]] |
| Script error: No such module "collapsible list". | |
L-759,633 is an analgesic drug which is a cannabinoid agonist. It is a fairly selective agonist for the CB2 receptor, with selectivity of 163x for CB2 over CB1.[1]
It produces some similar effects to other cannabinoid agonists such as analgesia, but with little or no sedative or psychoactive effects due to its weak CB1 activity, and a relatively strong antiinflammatory effect due to its strong activity at CB2.[2][3]
| 40px | This article about a cannabinoid is a stub. You can help ssf by expanding it. |
References
- ↑ Ross RA, Brockie HC, Stevenson LA, Murphy VL, Templeton F, Makriyannis A, Pertwee RG. Agonist-inverse agonist characterization at CB1 and CB2 cannabinoid receptors of L759633, L759656, and AM630. British Journal of Pharmacology. 1999 Feb;126(3):665-72. PMID 10188977
- ↑ Huffman JW. The search for selective ligands for the CB2 receptor. Current Pharmaceutical Design. 2000 Sep;6(13):1323-37. PMID 10903395
- ↑ Huffman JW. CB2 receptor ligands. Mini Reviews in Medicinal Chemistry. 2005 Jul;5(7):641-9. PMID 16026310
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