O-1238

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O-1238
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Systematic (IUPAC) name
(6aR)-3-[(Z)-6-azidohex-2-enyl]-6,6,9-trimethyl-6a,7,10,10a-tetrahydrobenzo[c]chromen-1-ol
Identifiers
PubChem CID 10761489
Chemical data
Formula C22H29N3O2
Molar mass 367.483 g/mol[[Script error: No such module "String".]]
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O-1238 is a drug which is a cannabinoid derivative that is used in scientific research. It is a partial agonist at the cannabinoid receptor CB1,[1] producing a maximal stimulation of 58.3%[2] with a Ki of 8.45nM.[3]


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References

  1. ↑ Griffin G, Wray EJ, Martin BR, Abood ME. Cannabinoid agonists and antagonists discriminated by receptor binding in rat cerebellum. British Journal of Pharmacology. 1999 Oct;128(3):684-8. PMID 10516649
  2. ↑ Griffin G, Wray EJ, Rorrer WK, Crocker PJ, Ryan WJ, Saha B, Razdan RK, Martin BR, Abood ME. An investigation into the structural determinants of cannabinoid receptor ligand efficacy. British Journal of Pharmacology. 1999 Apr;126(7):1575-84. PMID 10323589
  3. ↑ Ross RA, Gibson TM, Stevenson LA, Saha B, Crocker P, Razdan RK, Pertwee RG. Structural determinants of the partial agonist-inverse agonist properties of 6'-azidohex-2'-yne-delta8-tetrahydrocannabinol at cannabinoid receptors. British Journal of Pharmacology. 1999 Oct;128(3):735-43. PMID 10516656
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