JWH-200
From Self-sufficiency
| 180px | |
| Systematic (IUPAC) name | |
|---|---|
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(1-(2-morpholin-4-ylethyl)indol-3-yl)-naphthalen-1-ylmethanone | |
| Legal status | |
| Legal status |
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| Identifiers | |
| CAS Number | 103610-04-4 |
| PubChem | CID 10045570 |
| Chemical data | |
| Formula | C25H24N2O2 |
| Molar mass | 384.469 g/mol[[Script error: No such module "String".]] |
| Script error: No such module "collapsible list". | |
JWH-200 (WIN 55,225)[1] is an analgesic chemical from the aminoalkylindole family, which acts as a cannabinoid receptor agonist. Its binding affinity at the CB1 receptor is 42nM, around the same as that of THC,[2] but interestingly, its analgesic potency in vivo was higher than that of other analogues with stronger CB1 binding affinity in vitro,[3] around 3 times that of THC but with less sedative effect,[4] most likely reflecting favourable pharmacokinetic characteristics. It was discovered by, and named after, Dr. John W. Huffman.
References
- ↑ Dutta, AK; Ryan, W; Thomas, BF; Singer, M; Compton, DR; Martin, BR; Razdan, RK (1997). "Synthesis, pharmacology, and molecular modeling of novel 4-alkyloxy indole derivatives related to cannabimimetic aminoalkyl indoles (AAIs)". Bioorganic & medicinal chemistry. 5 (8): 1591–600. doi:10.1016/S0968-0896(97)00111-9. PMID 9313864.
- ↑ Huffman JW, Padgett LW. Recent Developments in the Medicinal Chemistry of Cannabimimetic Indoles, Pyrroles and Indenes. Current Medicinal Chemistry, 2005; 12: 1395-1411.
- ↑ Bell MR, D'Ambra TE, Kumar V, et al. (1991). Antinociceptive (aminoalkyl)indoles. Journal of Medicinal Chemistry. 34 (3): 1099–1110. PMID 1900533
- ↑ Compton DR, Gold LH, Ward SJ, Balster RL, Martin BR (1992). Aminoalkylindole analogs: cannabimimetic activity of a class of compounds structurally distinct from delta 9-tetrahydrocannabinol. Journal of Pharmacology and Experimental Therapeutics. 263 (3): 1118–26. PMID 1335057
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This Drug is legal and not controlled in Canada (up to date to may 14,2010)[1]
References
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