JWH-203

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JWH-203
File:JWH-203 structure.png
Systematic (IUPAC) name
2-(2-chlorophenyl)-1-(1-pentylindol-3-yl)ethanone
Identifiers
CAS Number 864445-54-5
PubChem CID 44397500
Chemical data
Formula C21H22ClNO
Molar mass 339.858 g/mol[[Script error: No such module "String".]]
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JWH-203 (1-pentyl-3-(2-chlorophenylacetyl)indole) is an analgesic chemical from the phenylacetylindole family, which acts as a cannabinoid agonist with approximately equal affinity at both the CB1 and CB2 receptors, having a Ki of 8.0nM at CB1 and 7.0nM at CB2. Similar to the related 2'-methoxy compound JWH-250, JWH-203 has a phenylacetyl group in place of the naphthoyl ring used in most aminoalkylindole cannabinoid compounds, and is the most potent compound found in the phenylacetyl group.[1][2] It was discovered by, and named after, Dr. John W. Huffman.

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References

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  1. ↑ Huffman JW, Szklennik PV, Almond A, Bushell K, Selley DE, He H, Cassidy MP, Wiley JL, Martin BR. 1-Pentyl-3-phenylacetylindoles, a new class of cannabimimetic indoles. Bioorganic and Medicinal Chemistry Letters. 2005 Sep 15;15(18):4110-3. PMID 16005223
  2. ↑ Manera C, Tuccinardi T, Martinelli A. Indoles and related compounds as cannabinoid ligands. Mini Reviews in Medicinal Chemistry. 2008 Apr;8(4):370-87. PMID 18473928
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