Difference between revisions of "JWH-210"

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JWH-210
File:JWH-210 structure.png
Systematic (IUPAC) name
4-ethylnaphthalen-1-yl-(1-pentylindol-3-yl)methanone
Identifiers
CAS Number 824960-64-7 (JWH-210)
619294-47-2 (JWH-122)
PubChem CID 45270396
Chemical data
Formula C26H27NO
Molar mass 369.498 g/mol[[Script error: No such module "String".]]
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JWH-210 is an analgesic chemical from the naphthoylindole family, which acts as a potent cannabinoid agonist at both the CB1 and CB2 receptors, with Ki values of 0.46nM at CB1 and 0.69nM at CB2. It is one of the most potent 4-substituted naphthoyl derivatives in the naphthoylindole series, having a higher binding affinity (i.e. lower Ki) at CB1 than both its 4-methyl and 4-n-propyl homologues (JWH-122 and JWH-182 respectively), and than the 4-methoxy compound JWH-081.[1] It was discovered and named after Dr. John W. Huffman.

File:JWH-122andJWH-182.png
JWH-122 and JWH-182

See also


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References

  1. ↑ Huffman, J.; Zengin, G.; Wu, M.; Lu, J.; Hynd, G.; Bushell, K.; Thompson, A.; Bushell, S.; Tartal, C. (2005). "Structure-activity relationships for 1-alkyl-3-(1-naphthoyl)indoles at the cannabinoid CB(1) and CB(2) receptors: steric and electronic effects of naphthoyl substituents. New highly selective CB(2) receptor agonists". Bioorganic & medicinal chemistry. 13 (1): 89–112. doi:10.1016/j.bmc.2004.09.050. PMID 15582455.  edit


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