Difference between revisions of "AMG-1"
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Latest revision as of 21:08, 21 September 2010
| 240px | |
| Systematic (IUPAC) name | |
|---|---|
|
(6aR,10aR)-3-(hept-1-ynyl)-6,6,9-trimethyl-
6a,7,10,10a-tetrahydrobenzo[c]chromen-1-ol | |
| Identifiers | |
| PubChem | CID 10830874 |
| Chemical data | |
| Formula | C23H30O2 |
| Molar mass | 338.482 g/mol[[Script error: No such module "String".]] |
| Script error: No such module "collapsible list". | |
AMG-1 is an analgesic drug which is a cannabinoid agonist. It is a derivative of Δ8THC with a rigidified and extended 3-position side chain. AMG-1 is a potent agonist at both CB1 and CB2 with moderate selectivity for CB1, with a Ki of 0.6nM at CB1 vs 3.1nM at CB2.[1]
| 40px | This article about a cannabinoid is a stub. You can help ssf by expanding it. |
References
- ↑ Papahatjis DP, Nikas SP, Kourouli T, Chari R, Xu W, Pertwee RG, Makriyannis A. Pharmacophoric requirements for the cannabinoid side chain. Probing the cannabinoid receptor subsite at C1'. Journal of Medicinal Chemistry. 2003 Jul 17;46(15):3221-9. PMID 12852753
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