JWH-133

JWH-133

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Systematic (IUPAC) name
(6aR,10aR)-3-(1,1-Dimethylbutyl)-6a,7,10,10a-tetrahydro -6,6,9-trimethyl-6H-dibenzo[b,d]pyran
Identifiers
CAS Number	259869-55-1
PubChem	CID 6918505
IUPHAR/BPS	747
Chemical data
Formula	C22H32O
Molar mass	312.489 g/mol[[]]

JWH-133 is a potent selective CB₂ receptor agonist, with a Ki of 3.4nM and selectivity of around 200x for CB₂ over CB₁ receptors. It was discovered by, and named after, John W. Huffman.

JWH-133, alongside WIN 55,212-2 and HU-210, is implicated in preventing the inflammation caused by Amyloid beta proteins involved in Alzheimer's Disease, in addition to preventing cognitive impairment and loss of neuronal markers. This antiinflamatory action is induced through agonist action at cannabinoid receptors, which prevents microglial activation that elicits the inflammation. Additionally, cannabinoids completely abolish neurotoxicity related to microglia activation in rat models.

It may be linked with anti-cancer properties, according to pre-trial data from a 2010 study in Madrid.

Legal Status

The substance commonly referred to as "JWH-133" is not a scheduled substance in the U.S., although its young age prevents it from having received the level of government attention as with the older, more widely used and well known chemicals. Low abuse potential makes it less likely for regulation a priori relative to its sister drugs such as JWH-018, as JWH-133 (chemical name (6aR,10aR)-3-(1,1-Dimethylbutyl)-6a,7,10,10a-tetrahydro -6,6,9-trimethyl-6H-dibenzo[b,d]pyran) is selective for the non-psychoactive CB₂ receptor and hence devoid of any psychoactive side effects or abuse potential.

External links

• JNeurosci.org Prevention of Alzheimer's Disease Pathology by Cannabinoids: Neuroprotection Mediated by Blockade of Microglial Activation