Ambenonium chloride

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Ambenonium chloride
File:Ambenonium.svg
Systematic (IUPAC) name
2,2'-[(1,2-dioxoethane-1,2-diyl)diimino]bis[N-(2-chlorobenzyl)-N,N-diethylethanaminium]
Clinical data
Routes of
administration
Oral
Pharmacokinetic data
Bioavailability Low
Identifiers
CAS Number 7648-98-8
ATC code N07AA30 (WHO)
PubChem CID 8288
DrugBank APRD00771
ChemSpider 7987
Chemical data
Formula C28H42Cl2N4O2Script error: No such module "String".
Molar mass 537.564 g/mol[[Script error: No such module "String".]]
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Ambenonium (as ambenonium dichloride, trade name Mytelase) is a cholinesterase inhibitor[1] used in the management of myasthenia gravis.

It is classified as reversible.[2]

Mechanism of Action

Ambenonium exerts its actions against Myasthenia Gravis by competitive reversible inhibition of acetylcholinesterase, the enzyme responsible for the hydrolysis of acetylcholine. Myasthenia Gravis occurs when the body produces antibodies against acetylcholine receptors, and thus inhibits signal transmission across the myoneural junction. Ambenonium reversibly binds acetylcholinesterase, inactivates it and therefore increases levels of acetylcholine. This, in turn, facilitates transmission of impulses across the myoneural junction and effectively treats the disease

Indications

Ambenonium is used to treat muscle weakness due to muscle disease (myasthenia gravis).

References

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ru:Амбенония хлорид
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