Talsaclidine

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Talsaclidine
File:Talsaclidine.png
Systematic (IUPAC) name
(3R)-3-(prop-2-yn-1-yloxy)-1-azabicyclo[2.2.2]octane
Pharmacokinetic data
Bioavailability 70%
Protein binding 7%
Excretion Renal (86%)
Identifiers
CAS Number 147025-53-4
ATC code none
PubChem CID 71792
ChemSpider 64819
Chemical data
Formula C10H15NO
Molar mass 165.23 g/mol[[Script error: No such module "String".]]
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Talsaclidine (WAL-2014) is a non-selective muscarinic acetylcholine receptor agonist which acts as a full agonist at the M1 subtype, and as a partial agonist at the M2 and M3 subtypes.[1][2][3] It was under development for the treatment of Alzheimer's disease but showed only modest or poor efficacy in rhesus monkeys and humans, respectively,[4][3] perhaps due to an array of dose-limiting side effects including increased heart rate and blood pressure, increased salivation, urinary frequency and burning upon urination, increased lacrimation and nasal secretion, abnormal accommodation, heartburn, upset stomach as well as cramps, nausea, vomiting, and diarrhea, excessive sweating, and palpitations.[5]

See also

References

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  1. Ensinger HA, Doods HN, Immel-Sehr AR; et al. (1993). "WAL 2014--a muscarinic agonist with preferential neuron-stimulating properties". Life Sciences. 52 (5-6): 473–80. PMID 8441328. 
  2. Walland A, Burkard S, Hammer R, Tröger W (1997). "In vivo consequences of M1-receptor activation by talsaclidine". Life Sciences. 60 (13-14): 977–84. PMID 9121364. 
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  5. Adamus WS, Leonard JP, Tröger W (1995). "Phase I clinical trials with WAL 2014, a new muscarinic agonist for the treatment of Alzheimer's disease". Life Sciences. 56 (11-12): 883–90. PMID 10188789.