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Systematic (IUPAC) name
Clinical data
  • US: C (Risk not ruled out)
Routes of
Legal status
Legal status
Pharmacokinetic data
Bioavailability ?
Metabolism Hepatic (cytochrome P450 system)
Biological half-life 8-10 hours (30 hours for major metabolites)
Excretion Renal
CAS Number 14028-44-5
ATC code N06AA17 (WHO)
PubChem CID 2170
DrugBank APRD00142
ChemSpider 2085
Chemical data
Formula C17H16ClN3O
Molar mass 313.781[[Script error: No such module "String".]]
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Amoxapine (Asendin, Asendis, Defanyl, Demolox, Moxadil) is a tetracyclic antidepressant (TeCA) of the dibenzoxazepine class. Though some authorities classify it as a secondary amine tricyclic antidepressant.


Amoxapine is used in the treatment of depression, anxiety disorders, panic disorder, and bipolar disorder. Amoxapine is contra indicated in children because it lower the seizure threshold to the extent that fits may be precipitated, specially in children. Cardiovascular effects and anti-cholinergic side effects are much reduced. It also has action similar to an atypical antipsychotic.[1]


Amoxapine is a strong norepinephrine reuptake inhibitor and weak serotonin reuptake inhibitor. It also possesses antiadrenergic, anticholinergic, antidopaminergic, antihistamine, and antiserotonergic actions.

Side effects

One of its major metabolites, 7-hydroxyamoxapine, has a dopamine receptor blocking effect, making this drug a common cause of neuroleptic malignant syndrome. Amoxapine is also associated with acute extrapyramidal symptoms and tardive dyskinesia.

Special precautions

mania, hypomania, severe liver damage, diabetes, myocardial infarction, Epilepsy.

Drug Interactions

potential seductive effects of alcohol, antiparkinson, agents, reduce effects of sympathomimetics.

See also


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Further reading

  • Mosby Year-Book, Inc. (1995). Physician's GenRx: The Complete Drug Reference (5th Ed.). Riverside, CT: Denniston Publishing Co.
  • Palfai, T. & Jankiewicz, H. (1997). Drugs and Human Behavior (2nd Ed.). Madison, WI: Brown & Benchmark.
  • Hedges, D. & Burchfield, C. (2006). Mind, Brain, and Drug: An Introduction to Psychopharmacology. Boston, MA: Pearson.

fr:Amoxapine ja:アモキサピン pt:Amoxapina

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