|Systematic (IUPAC) name|
|Biological half-life||13 hours|
|ATC code||A01AD02 (WHO) G02 M01 M02|
|Molar mass||309.405 g/mol[[Script error: No such module "String".]]|
|Script error: No such module "collapsible list".|
Benzydamine, available as the hydrochloride, is a locally-acting nonsteroidal anti-inflammatory drug with local anaesthetic and analgesic properties providing both rapid and extended pain relief as well as a significant anti-inflammatory treatment for the painful inflammatory conditions of the mouth and throat.
It may be used alone or as an adjunct to other therapy giving the possibility of increased therapeutic effect with little risk of interaction.
It is available in a mouth wash named Tantum Verde across Europe.
It is available in gel or oral rinse form with trade name Tantum (Elder Pharmaceutical) in India
In the UK it is available without prescription from pharmacies; it is produced in the UK by Meda Pharmaceuticals under the trade name Difflam, and is available as a spray, oral rinse and cream, and as lozenges.
In Australia and New Zealand it is available from 3M as Difflam-C Alcohol & Colour Free Solution, Difflam 3% Gel, Difflam Extra Strength Gel 5%, Difflam-C Solution, Difflam Solution (including Difflam Throat Spray), Difflam Cream and Difflam Lozenges.
It is sold in eastern Europe without prescription as Tantum Rosa - a vaginal antiseptic and anti-inflammatory, containing 0.5 g of benzydamine hydrochloride to be reconstituted with clean water to a 0.1% (1 mg/mL) solution for vaginal enema/instillation.
In Pakistan it is sold by prescription under the name Tantum Capsule (50mg).
It is available in a cream and gel named Tantum Fort across Egypt by EIPICo.
It is available with prescription as a mouthwash named Novo-Benzydamine (Novopharm) in Canada.
In Mexico it is sold by prescription under the name Vantal as a mouth rinse.
In Argentina it is sold as a mouthwash under the name Ernex, manufactured by Casasco.
There are no contraindications to the use of Benzydamine except for known hypersensitivity.
Benzydamine is well tolerated. Occasionally oral tissue numbness or stinging sensations may occur. Benzydamine may be abused recreationally. In oral dosages of 500 mg to 3000 mg it is a deliriant and CNS stimulant (a cough drop has 3 mg dose), popular in Poland, Brazil and Romania. In Brazil it is very popular and widely used for recreational purposes, particularly among teenagers and as a club drug. A person in a benzydamine trip may experience (because of large dopamine release) a feeling of well-being, euphoria and, in higher doses, hallucinations, paranoia, dry mouth and convulsions. The trip can last up to 8 hours, after that the user becomes tired and quiet, but sleeping is almost impossible. Unlike other NSAIDs, it does not inhibit cyclooxygenase or lipooxygenase, and is not ulcerogenic.
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- Turnbull RS. Benzydamine Hydrochloride (Tantum) in the management of oral inflammatory conditions. Journal of the Canadian Dental Association. 1995 Feb;61(2):127-34.
- Material Safety Data Sheets for Difflam varieties sold in Australia
- 3M Pharmaceuticals S.A. (Pty) Ltd
- Anand JS, Glebocka ML, Korolkiewicz RP. Recreational abuse with benzydamine hydrochloride (tantum rosa). Clinical Toxicology (Philadelphia, Pa). 2007;45(2):198-9.
- Alves L (n.d.). "Benflogin (cloridrato de benzidamina)" (in Portuguese). Brasil Escola. Retrieved on November 5, 2008.