JWH-081

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JWH-081
File:JWH-081.svg
Systematic (IUPAC) name
4-methoxynaphthalen- 1-yl- (1-pentylindol- 3-yl)methanone
Legal status
Legal status
  • Legal
Identifiers
CAS Number 210179-46-7
PubChem CID 10547208
Chemical data
Formula C25H25NO2
Molar mass 371.47 g/mol[[Script error: No such module "String".]]
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JWH-081 is an analgesic chemical from the naphthoylindole family, which acts as a cannabinoid agonist at both the CB1 and CB2 receptors.[1] It is fairly selective for the CB1 subtype, with affinity at this subtype approximately 10x the affinity at CB2.[2] It was discovered and named after Dr. John W. Huffman.

See also

References

  1. ↑ Aung MM, Griffin G, Huffman JW, Wu MJ, Keel C, Yang B, Showalter VM, Abood ME, Martin BR. Influence of the N-1 alkyl chain length of cannabimimetic indoles upon CB1 and CB2 receptor binding. Drug and Alcohol Dependence 2000; 60:133-140.
  2. ↑ Huffman JW, Zengin G, Wu MJ, Lu J, Hynd G, Bushell K, Thompson ALS, Bushell S, Tartal C, Hurst DP, Reggio PH, Selley DE, Cassidy MP, Wiley JL, Martin BR. Structure–activity relationships for 1-alkyl-3-(1-naphthoyl)indoles at the cannabinoid CB1 and CB2 receptors: steric and electronic effects of naphthoyl substituents. New highly selective CB2 receptor agonists. Bioorganic and Medicinal Chemistry. 2005; 13:89-112.
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