Tetracaine

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Tetracaine
File:Tetracaine.svg
Systematic (IUPAC) name
2-(dimethylamino)ethyl 4-(butylamino)benzoate
Clinical data
Routes of
administration		 Topical, Epidural, Spinal
Legal status
Legal status
  • ℞ (Prescription only)
Pharmacokinetic data
Protein binding 75.6
Identifiers
CAS Number 94-24-6
136-47-0 (hydrochloride)
ATC code C05AD02 (WHO) D04AB06 N01BA03 S01HA03
PubChem CID 5411
Chemical data
Formula C15H24N2O2
Molar mass 264.363 g/mol[[Script error: No such module "String".]]
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Tetracaine (INN, also known as amethocaine; trade name Pontocaine and Dicaine) is a potent local anesthetic of the ester group. It is mainly used topically in ophthalmology and as an antipruritic, and it has been used in spinal anesthesia.

In biomedical research, tetracaine is used to alter the function of calcium release channels (ryanodine receptors) that control the release of calcium from intracellular stores. Tetracaine is an allosteric blocker of channel function. At low concentrations, tetracaine causes an initial inhibition of spontaneous calcium release events, while at high concentrations, tetracaine blocks release completely[1].

References

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Antihemorrhoidals for topical use
Antivaricose therapy
Capillary stabilising agents
Antihistamines for topical use
Anesthetics for topical use

M: INT, SF, LCT

noco(i/b/d/q/u/r/p/m/k/v/f)/cong/tumr(n/e/d), sysi/epon

proc, drug (D2/3/4/5/8/11)

Anesthetics: Local anesthetics - primarily sodium channel blockers (N01B)
Esters
Amylocaine • Benzocaine • Butacaine • Butamben • Chloroprocaine • Dimethocaine • Meprylcaine • Metabutoxycaine • Orthocaine • Propoxycaine • Procaine (Novocaine) • Proxymetacaine • Risocaine • Tetracaine
Esters of benzoic acid
Amides
Combinations

M: PNS

anat(h, r, t, c, b, l, s)/phys/devp

proc, drug(N1B)


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de:Tetracain

fr:Tétracaïne hu:Tetrakain ja:テトラカイン

pt:Tetracaína
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