Fluocinolone acetonide

From Self-sufficiency

Fluocinolone acetonide
Systematic (IUPAC) name
File:Fluocinolone acetonide.svg
(1S,2S,4R,8S,9S,11S,12R,13S,19S)-12,19-difluoro-11-hydroxy-8-(2-hydroxyacetyl)-6,6,9,13-tetramethyl-5,7-dioxapentacyclo[10.8.0.0^2,9.0^4,8.0^13,18]icosa-14,17-dien-16-one
Clinical data
Pregnancy category	C
Routes of administration	Topical
Pharmacokinetic data
Metabolism	Hepatic, CYP3A4-mediated
Biological half-life	1.3 to 1.7 hours

Identifiers
CAS Number	67-73-2
ATC code	C05AA10 (WHO) D07AC04 S01BA15 S02BA08
PubChem	CID 6215
DrugBank	APRD00977
Chemical data
Formula	C₂₄H₃₀F₂O₆
Molar mass	452.488 g/mol[[Script error: No such module "String".]]

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Fluocinolone acetonide is a corticosteroid primarily used in dermatology to reduce skin inflammation and relieve itching. It is a synthetic hydrocortisone derivative. The fluorine substitution at position 9 in the steroid nucleus greatly enhances its activity. A typical dosage strength used in dermatology is 0.01–0.025%. One such cream is sold under the brand name Flucort-N and includes the antibiotic neomycin.

Corticosteroids – glucocorticoid/receptor and mineralocorticoid/receptor
(A07EA, C05AA, D07, D10AA, H02, R01AD, R03BA, S01BA, S02B, and S03B) (Endogenous in CAPS)

Mineralocorticoids
(3-one, 4-ene,
no FG at 16)

Pregnenedione: ALDOSTERONE · 11-DEOXYCORTICOSTERONE · HALOGENATED AT 9: Fludrocortisone

Glucocorticoids
(3-one, 4-ene,
11-FG,
17-hydroxy)

Pregnene	CORTISONE
Pregnenedione (+20-one)	HYDROCORTISONE/CORTISOL^# (Hydrocortisone aceponate, Hydrocortisone buteprate, Hydrocortisone butyrate) · Budesonide · Ciclesonide · Deflazacort · Medrysone · Tixocortol · HALOGENATED AT 6: Cloprednol · HALOGENATED, WITH FG AT 16: Halcinonide
Pregnadiene (+1-ene)	Rimexolone · HALOGENATED, WITH FG AT 16: Flunisolide · Triamcinolone · Amcinonide · Fluocinolone acetonide (Fluocinonide)
Pregnadienediol (+21-hydroxy)	Prednisone (Meprednisone) · HALOGENATED AT 9: Fluorometholone · HALOGENATED, WITH FG AT 16: Fluocortolone (Clocortolone, Diflucortolone, Fluocortin) · Desoximetasone
Pregnadienetriol (+11-hydroxy)	Prednisolone^# (Methylprednisolone, Methylprednisolone aceponate, Prednicarbate, Prednylidene) · Desonide · HALOGENATED: Fluprednisolone (Difluprednate, Fluperolone) · HALOGENATED, WITH FG AT 16: Dexamethasone^# · Betamethasone (Clobetasol, Clobetasone, Diflorasone, Halometasone, Ulobetasol) · Beclometasone · Paramethasone · Alclometasone · Fluclorolone · Flumetasone · Fluprednidene
Pregnatriene (+2-ene)	Cortivazol
Androstene	HALOGENATED, WITH FG AT 16: Fluticasone (Fluticasone propionate, Fluticasone furoate)
Other/ungrouped	HALOGENATED: Loteprednol · HALOGENATED, WITH FG AT 16: Fludroxycortide · Formocortal · Mometasone furoate