Dipropylcyclopentylxanthine

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Dipropylcyclopentylxanthine
File:8-Cyclopentyl-1,3-dipropylxanthine.png
Systematic (IUPAC) name
8-cyclopentyl-1,3-dipropyl-7H-purine-2,6-dione
Legal status
Legal status
  • Uncontrolled
Identifiers
CAS Number 102146-07-6
ATC code none
PubChem CID 1329
IUPHAR/BPS 386
Chemical data
Formula C16H24N4O2
Molar mass 304.386 g/mol[[Script error: No such module "String".]]
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Physical data
Melting point 191 to 194 °C (376 to 381 °F)
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8-Cyclopentyl-1,3-dipropylxanthine (DPCPX, PD-116,948) is a drug which acts as a potent and selective antagonist for the adenosine A1 receptor.[1][2] It has high selectivity for A1 over other adenosine receptor subtypes, but as with other xanthine derivatives DPCPX also acts as a phosphodiesterase inhibitor, and is almost as potent as rolipram at inhibiting PDE4.[3] It has been used to study the function of the adenosine A1 receptor in animals,[4][5] which has been found to be involved in several important functions such as regulation of breathing[6] and activity in various regions of the brain,[7][8] and DPCPX has also been shown to produce behavioural effects such as increasing the hallucinogen-appropriate responding produced by the 5-HT2A agonist DOI,[9] as well as having interactions with a range of anticonvulsant drugs.[10][11]

See also

References

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Receptor ligands
Reuptake inhibitors
ENT inhibitors
VNT inhibitors
 
PDE1
PDE2
PDE3
PDE4
PDE5
PDE6
PDE7
PDE9
PDE10
Nonselective


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  1. ↑ Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
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  6. ↑ Vandam RJ, Shields EJ, Kelty JD (2008). "Rhythm generation by the pre-Bötzinger complex in medullary slice and island preparations: effects of adenosine A(1) receptor activation". BMC Neuroscience. 9: 95. doi:10.1186/1471-2202-9-95. PMC 2567986 Freely accessible. PMID 18826652. 
  7. ↑ Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
  8. ↑ Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
  9. ↑ Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
  10. ↑ Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
  11. ↑ Chwalczuk K, Rubaj A, Swiader M, Czuczwar SJ (2008). "[Influence of the antagonist of adenosine A1 receptors, 8-cyclopentyl-1 ,3-dipropylxanthine, upon the anticonvulsant activity of antiepileptic drugs in mice]". Przegla̧d Lekarski (in Polish). 65 (11): 759–63. PMID 19205356. 
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